Evidence-Based Complementary and Alternative Medicine / 2011 / Article / Tab 1

Research Article

Gastroprotective Effect of Rubia cordifolia Linn. on Aspirin Plus Pylorus-Ligated Ulcer

Table 1

Effect of R. cordifolia on gastric acid secretion and ulcer index.

Sr. No.123456789101112

GroupNormalControlStandardME 100ME 200ME 400CF 50CF 100CF 200RF 50RF 100RF 200
Ulcer Index (%protection) (72.86) (14.64) (17.84) (32.50) (35.02) (49.37) (61.71) (9.59) (12.16) (13.61)
Pepsin (nmols of tyrosine/mL)
Protein (μg/mL)
Mucin Content (μg of alcian blue/g wet tissue)
Total Acidity (meq/L/4 hr)1088.28 ± 22.291939.21 ±   1195.26 ± 37.031844.82 ± 28.7 1775.82 ± 29.26*1533.62 ± 15.72**1545.82 ± 40.83**1340.32 ± 41.94**1226.42 ± 38.14** 1648.82 ± 29.64**
Total acid Output (meq/L/4 hr)2459.08 ± 81.979318.16 ± 328.2 3068.32 ± 103.24 7280.47 ± 708.72**6180.48 ± 172.84**7574.04 ± 539.46*5671.92 ± 308.91**4741.44 ± 41.17** 7612.26 ± 359.52*

normal group= vehicle Na CMC 1% (10 ml/kg, p.o.).
Values are expressed as mean ± SEM. Control group was compared with normal group. Test and standard groups were compared with control group. Statistical comparison was performed using analysis of variance (ANOVA) followed by Turkey’s test. ; , when compared with normal group. * ; ** ; *** ; NS: nonsignificant, when compared with control groups.
ME100, 200, and 400—methanolic extract of Rubia cordifolia 100, 200, and 400 mg/kg, p.o,. respectively, CF50,100, and 200—chloroform fraction of Rubia cordifolia 50, 100, and 200 mg/kg, p.o., respectively, RF50,100, and 200—residual fraction of Rubia cordifolia 50, 100, and 200 mg/kg, p.o., respectively.

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