Evidence-Based Complementary and Alternative Medicine / 2011 / Article / Tab 2

Research Article

Gastroprotective Effect of Rubia cordifolia Linn. on Aspirin Plus Pylorus-Ligated Ulcer

Table 2

Effect of R. cordifolia on antioxidant parameters in stomach of aspirin + pylorus-ligated rats.

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GroupNormalControlStandardME 100ME 200ME 400CF 50CF 100CF 200RF 50RF 100RF 200
SOD (Units/gm of wet tissue)204.4 ± 3.61 125.2 ± 2.38*** 112.36 ± 2.94***110.84 ± 3.72**132.92 ± 2.65***172.06 ± 7.22*** 106.14 ± 2.2*
CAT (Units/gm of wet tissue)45.97 ± 2.12 40.35 ± 1.25*** 23.73 ± 1.26**26.3 ± 1.47***24.3 ± 1.86**29.73 ± 2.05***34.4 ± 2.02***
GSH (nmols/gm of wet tissue)218.4 ± 6.43 142.9 ± 6.72***122.22 ± 4.4*127.28 ± 4.72**150.52 ± 3.84***123.96 ± 4.97**155.4 ± 4.52***176.42 ± 4.59*** 120.4 ± 4.81*
LPO (nmols of MDA/gm of wet tissue)139.68 ± 4.27 235.64 ± 6.19* 229.24 ± 5.38**183.46 ± 3.76***199.66 ± 4.74***177.76 ± 3.95***155.94 ± 2.73*** 230.1 ± 3.9**

normal group= vehicle Na CMC 1% (10 ml/ kg, p.o.).
Values are expressed as mean ± SEM. Control group was compared with normal group. Test and standard groups were compared with control group. Statistical comparison was performed using analysis of variance (ANOVA) followed by Turkey’s test. , when compared with normal group. * ; ** ; *** ; NS: nonsignificant, when compared with control groups.
ME100, 200, and 400—methanolic Extract of Rubia cordifolia 100, 200, and 400 mg/kg, p.o., respectively, CF50,100, and 200—chloroform fraction of Rubia cordifolia 50, 100, and 200 mg/kg, p.o., respectively, RF50,100, and 200—residual fraction of Rubia cordifolia 50, 100, and 200 mg/kg, p.o., respectively.

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