Suppression of Heregulin-<i>β</i>1/HER2-Modulated Invasive and Aggressive Phenotype of Breast Carcinoma by Pterostilbene via Inhibition of Matrix Metalloproteinase-9, p38 Kinase Cascade and Akt Activation

<table>Schematic models depicting the effects of pterostilbene on HRG-<i>β</i>1-mediated aggressive phenotypes of MCF-7 cells. PTER: pterostilbene; HRG-<i>β</i>1: heregulin-<i>β</i>1; PI3K: phosphotidylinositol 3-kinase; PDK: phosphotidylinositol-3,4,5-triphosphate dependent kinase; p38 kinase, p38 MAP kinase; AP-1: activator protein-1; ECM: extracellular matrix. The arrow symbol represents direct or multistep activation; the T-like symbol represents site of inhibition by pterostilbene.</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 8

Figure 8: Suppression of Heregulin-<i>β</i>1/HER2-Modulated Invasive and Aggressive Phenotype of Breast Carcinoma by Pterostilbene via Inhibition of Matrix Metalloproteinase-9, p38 Kinase Cascade and Akt Activation 

Figure 8 | Suppression of Heregulin-β1/HER2-Modulated Invasive and Aggressive Phenotype of Breast Carcinoma by Pterostilbene via Inhibition of Matrix Metalloproteinase-9, p38 Kinase Cascade and Akt Activation 