Modulation of Hypoxia-Induced Pulmonary Vascular Leakage in Rats by Seabuckthorn (Hippophae rhamnoides L.)
Figure 7
Reduction of VEGF immunohistochemical staining after pretreatment with DEXA and SBT LE (100 mg/kg bw) in rats exposed to simulated high altitude of 9144 m for 5 h. Minimal VEGF immunostaining was evident in lung parenchyma in control animals in contrast to abundant VEGF immunostaning in the hypoxic group. Pretreatment with DEXA, SBT LE reduced VEGF staining and maintained the capillary integrity. The photographs are representative of three animals examined under each condition. Original magnification: ×200.
