Centella asiatica Improves Physical Performance and Health-Related Quality of Life in Healthy Elderly Volunteer

Table 2

Effect of C. asiatica on physical fitness measured by 30-s chair stand test and 6-min walk test.

Items	Pre-dose baseline score		Post-dose score
			1 month	2 month	3 month	Delay
30-s chair stand test (times)					16.05±2.72	16.10±3.67
	Placebo	15.85 ± 2.87	15.65 ± 2.80	15.70 ± 2.99	𝐹(0.0500,3.57)=0.3352,	𝐹(0.0500,1.19)=0.1351,
					𝑃=.7999	𝑃=.7172
					20.35±4.82^a,∗∗	18.60±5.96
	CA250	16.85 ± 4.21	18.40 ± 4.07	18.35 ± 4.85	𝐹(0.0500,3.57)=5.2662,	𝐹(0.0500,1.19)=2.2391,
					𝑃=.0028	𝑃=.1510
					20.35±3.66^b,∗∗	17.30±4.03
	CA500	16.80 ± 4.36	17.75 ± 3.80	19.90±4.10^a,∗∗	𝐹(0.0500,3.57)=23.3794,	𝐹(0.0500,1.19)=1.3768,
					𝑃<.0001	𝑃=.2551
					21.00±4.48^b,∗∗∗	17.90±5.93
	CA750	16.80 ± 3.09	17.45 ± 3.53	18.55±3.17^a,∗	𝐹(0.0500,3.57)=13.9752,	𝐹(0.0500,1.19)=0.9200,
					𝑃<.0001	𝑃=.3495
6 min walk test (meters)					518.35±59.62	510.55±78.06
	Placebo	515.60 ± 42.18	509.45 ± 55.78	504.95 ± 57.32	𝐹(0.0500,3.57)=1.0645,	𝐹(0.0500,1.19)=0.1759,
					𝑃=.3714	𝑃=.6796
					535.60±52.40	519.25±81.86
	CA250	517.60 ± 59.75	527.95 ± 42.34	524.25 ± 49.77	𝐹(0.0500,3.57)=1.6551,	𝐹(0.0500,1.19)=0.0155,
					𝑃=.1869	𝑃=.9022
					521.35±66.20	512.00±67.95
	CA500	509.50 ± 57.38	517.00 ± 64.62	523.10 ± 67.8	𝐹(0.0500,3.57)=1.8655,	𝐹(0.0500,1.19)=0.0355,
					𝑃=.1457	𝑃=.8526
					524.75±80.68	520.55±87.65
	CA750	511.75 ± 54.12	517.80 ± 75.67	529.05 ± 82.27	𝐹(0.0500,3.57)=1.2784,	𝐹(0.0500,1.19)=0.5046,
					𝑃=.2905	𝑃=.4861

Subjects were measured physical fitness measured by 30-s chair stand test and 6-min walk test. Data are presented as mean ± SD. 𝑃- and 𝐹-values were compared between pre-dose baseline score and post-dose 1, 2, 3 month and 1 month after cessation of treatment (𝑛 = 20/group).^a,b𝑃-value <.01 and.001 compared with pre-dose baseline score, respectively.
*, **, ^∗∗∗𝑃-value <.05,.01 and.001 compared with placebo treated group, respectively.