Figure 3: The effectiveness of Kampo formulae on the target symptom; the primary endpoint. The target symptoms were general fatigue for Hochu-ekki-to, skin symptoms for Keigai-rengyo-to, neurological symptoms for Gosha-jinki-gan and respiratory symptoms for Bakumondo-to. The effectiveness of the Kampo formulae was evaluated by changes in intensity of the symptoms from baseline to the end of administration, which was measured by VAS. Differences in effectiveness between the formulae administered for the target symptom and other formulae for the same symptom are shown. Data are means (dots) and 95% confidence intervals (bars). Bakumondo-to significantly improved respiratory symptoms compared with other formulae. by Student’s t-test.