589724.fig.006a
(a)
589724.fig.006b
(b)
Figure 6: Hypothetical diagrams of the effect of Bakumondo-to. (a) After ligation of dioxins to the AhR, the receptor translocates from the cytosol to the nucleus, binds to DRE, and activates transcription of CYP1A1, mucin and other genes in bronchiolar Clara cells. Excess mucin production from Clara cells by dioxins is supposed to be responsible at least in part for respiratory symptoms of Yusho patients. (b) Active ingredients in Bakumondo-to would block activation of the AhR by competitive interference with the interaction between dioxins and the AhR, and inhibit transcription of mucin in Clara cells, leading to improvement of respiratory symptoms of Yusho patients.