Attenuation of Diabetic Nephropathy in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats with a Combination of Chinese Herbs (Tangshen Formula)
Figure 4
Periodic acid-Schiff staining of glomeruli of the rats at 36 weeks of age: (a) control LETO group; (b) control OLETF group, (c) OLETF + TSF group, (d) OLETF+Monopril group; and at 56 weeks of age: (e) control LETO group; (f) control OLETF group, (g) OLETF + TSF group, (h) OLETF + Monopril group, in diabetic OLETF rats, mesangial expansion accompanied by an accumulation of extracellular matrix and glomerular capillary wall thickening occurs at 36 weeks of age. Diffuse glomerularsclerosis and mesangial matrix expansion happened at 56 weeks of age. These glomerular changes are ameliorated by TSF and monopril treatment. Pictures is at the magnification of ×400.
