Table 1: Items to be included when reporting experiments in REHBaR.


Title1Title indicates the experimental model and intervention
Abstract2Abstract provides an informative and balanced summary of what was done and found

Background3Scientific background, presentation of experimental model(s). explanation of rationale, including homeopathic principles (e.g., similia principle, potentization, proving) and type of homeopathy (isopathy, classical versus complex homeopathy)
Objectives/Hypotheses4Objectives and hypotheses with outcome measures. For confirmatory experiments: specific hypotheses and clearly defined primary outcome measure. For exploratory experiments: hypotheses inducing the investigations

Materials and methods
Materials5Detailed description of all used materials (e.g., biological system, devices, substances, instruments)
Materials (homeopathy specific)6Manufacturer, pharmacopoeia (or process) of medications, potency and steps of dilution, dilution method, substance starting point of dilution (e.g., mother tincture. D1, nosode)
Homeopathic controls7Precise details on the preparation of the control substance
System performance controls8Report on negative and positive controls
Quality control9Procedures and efforts used to enhance the quality and reliability of the experimental procedure
Object of investigation10Selection criteria for the particular system used: in vivo, in vitro, biological, physical, biochemical
Experimental setup11Detailed description of experimental conditions and procedure
Replication21If experiment has internal replications, detailed description is given of which materials were reused and which have been changed
Parameters13All measured parameters described in detail
Intervention14Precise details of the interventions intended for each group and how and when they were actually administered
Allocation15Method used to generate the group allocation including details (e.g., randomization, blocking, stratification)
Blinding16Description if any procedures or interventions were concealed (if yes, details given)
Statistical methods17Statistical tests and procedure of calculation are described: Methods for additional analyses like adjusted analyses

Numbers analysed18Number of experiments with exact number of treated units per setting which were included in each analysis and reporting missing samples, drop outs
Data (descriptive)19Results are given in tables or figures showing mean or median together with variability (e.g., SD and/or range) for absolute data (and differences)
Data (inferential)20Gives appropriate measures of effect size uncertainty and probability
Interpretation21Interpretation of the results, taking into account study hypotheses, sources of potential bias or imprecision
Evidence22General interpretation of results in the context of current evidence. Discuss the generalizability/external validity of the study results
Experimental model23Explanation why this model, these parameters were chosen and its adequacy for answering the questions including homeopathic aspects