Radiation-Induced Testicular Injury and Its Amelioration by Tinospora cordifolia (An Indian Medicinal Plant) Extract

Table 2

Variation in tubular diameter, lipid peroxidation, and glutathione in mice after exposure to 7.5 Gy gamma radiation with (experimental) or without (irradiated control) Tinospoa cordifolia extract. The values represent mean ± S.E. The statistical significance was obtained between normal versus irradiated control and irradiated control versus experimental (𝑃<  * =  .05, ** =  .01, *** =  .001).

Parameter	Group	Posttreatment autopsy intervals
		12 hrs	24 hrs	3 days	7 days	15 days	30 days
Peripheral tubular diameter (192±16.2* μm)	II	192±16.52	192±16.43	192.61±16.44	194±16.21	195.23±33	196.11±64
	III	147.24±10.02 *	143.13±8.3 *	135.2±9.3 *	120.48±3.41 **	98.12±4.31 ***	N.S.
	IV	153.54±10.11	150.02±11.02	144.55±9.71	134.44±9.3	118.87±6.2 *	128.99±4.52 *
Central tubular diameter (157.74±13.12* μm)	II	167.37±14.01	169.16±13.161	170.63±13.2	172.17±14.22	173.47±14.00	174.49±13.22
	III	121.42±4.47 *	115.30±6.11 **	106.71±7.12 **	96.73±3.27 ***	88.59±4.12 ***	N.S.
	IV	133.63±5.48	128.62±4.32	121.8±4.33	113.95±5.61 *	107.83±6.18 *	120.15±7.58 *
Lipid-per oxidation (1.63±0.24* n mole/gm tissue)	I	1.52±0.09	1.48±0.11	1.36±0.06	1.28±0.13	1.17±0.14	1.08±0.22
	II	4.57±0.73 *	5.58±0.78 ***	8.50±0.72 ***	12.6±0.83 ***	14.3±0.93 ***	N.S.
	III	6.56±0.86	3.59±0.15 *	3.99±0.25 ***	5.29±0.42 ***	5.07±0.22 ***	5.03±0.26 ***
Glutathione (5.862±0.72* μ mole/gm)	II	5.884±0.31	5.953±0.28	6.032±0.36	6.128±0.41	6.168±0.44	6.218±0.39
	III	2.88±0.52 **	2.4±0.43 **	1.25±0.18 ***	0.17±0.03 ***	1.77±0.13 ***	N.S.
	IV	3.669±0.07	3.627±0.52	2.954±0.62 *	2.089±0.52 *	3.248±0.53 *	4.121±0.31 ***

NS: Non survival, *represents Group I: Normal/Sham-irradiated, Group II: Negative control, Group III: Irradiated Control, Group IV: Experimental.