Original Article

Antioxidant and Hepatoprotective Effects of Silibinin in a Rat Model of Nonalcoholic Steatohepatitis

Figure 1

Effect of silibinin on glycemic homeostasis. Glycemia (a) was measured in whole blood and insulin (b) was measured in plasma obtained from rats in the fasting state, after 12 weeks of standard diet (control) or high-fat diet alone (NASH), or supplemented with silibinin–phosphatidylcholine complex (Silibinin), at a dose of 200 mg kg−1 as silibinin, during the last 5 weeks. HOMA-IR (c) is indicative of the insulin resistance state for the animals. Values are expressed as means ± SE of six rats for Control and NASH groups and of eight rats for Silibinin group. * versus Control group. versus NASH group.
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(a)
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(b)
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(c)