The Ethanol Extract of Fructus trichosanthis Promotes Fetal Hemoglobin Production via p38 MAPK Activation and ERK Inactivation in K562 Cells
Hypothetical diagram to illustrate the actions of FT-EtOH on MAPK family in HbF induction. After FT-EtOH treatment, activation of p38 and inhibition of ERK lead to HbF production and subsequently increase total hb level in K562 cell. However, SAPK does not involve in FT-EtOH-induced erythroid differentiation process.
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