Original Article

Mechanism of Wound-Healing Activity of Hippophae rhamnoides L. Leaf Extract in Experimental Burns

Table 1

Effect of topical application of SBT lyophilized aqueous leaf extract on wound area contraction (mm2).

Post wounding dayBurn controlSBT aqueous leaf extractSSD
2.5% (w/w)5.0% (w/w)7.5% (w/w)10.0% (w/w)

Day 0176.83 ± 0.87177.67 ± 1.26178.33 ± 0.99179.17 ± 0.60177.33 ± 0.99176.5 ± 1.80
Day 4138.50 ± 4.60 (22)124.50 ± 2.79 (30)113.17 ± 3.48* (37)121.33 ± 3.57* (32)133.00 ± 3.17 (25)128.83 ± 5.28 (27)
Day 890.83 ± 2.63 (49)71.67 ± 3.68* (60)50.33 ± 3.84* (71)63.33 ± 3.79*(65)79.00 ± 3.48 (55)72.00 ± 4.33* (59)

Values are mean ± SE; n = 6; Numbers in parenthesis indicate percentage of wound contraction.
* P < .05 compared with burn control.