Characterization of the Antidiabetic Role of Parkinsonia aculeata (Caesalpineaceae)

Figure 5

Schematic representation of the proposed effects of the HEPA treatment in alloxan-induced diabetic rats. The group of diabetic rats which were treated with the HEPA showed a significant reduction in serum and urinary glucose, urinary urea, and triglyceride levels. Also, an improvement in hepatic glycogen was observed as well as a decrease in liquid intake and urinary volume, and an enhancement in the weight of skeletal muscles, kidneys, liver, and adipose tissue. Indeed, oral glucose tolerance was higher in diabetic animals treated with HEPA. Together, all observed changes in some of the measured parameters, suggests a reduction on the gluconeogenesis process.