Antiosteoporotic Activity of Dioscorea alata L. cv. Phyto through Driving Mesenchymal Stem Cells Differentiation for Bone Formation

Table 1

Effects of Dispo85E on tBMD and morphometric parameters of distal femur in OVX model.

Parameters	Sham	OVX + Dispo85E (mg/kg/day)
		0	40	200	1000
tBMD (g/cm^3)	0.088 ± 0.003	0.054 ± 0.008*	0.083 ± 0.003^‡	0.063 ± 0.009*	0.081 ± 0.006^‡
BV/TV (%)	4.34 ± 0.36	2.56 ± 0.44*	4.17 ± 0.29^†	3.50 ± 0.69	4.11 ± 0.39^†
Tb.Th (μm)	60.7 ± 1.03	59.30 ± 0.71	64.36 ± 2.25	63.15 ± 2.70	63.03 ± 2.26
Tb.N (1/mm)	0.72 ± 0.06	0.43 ± 0.07*	0.65 ± 0.04^†	0.55 ± 0.10	0.66 ± 0.06^†

Values are expressed as mean ± SD; n = 5-6/group. tBMD: trabecular bone mineral density; BV/TV: bone volume fraction; Tb.Th: trabecular thickness; Tb.N: trabecular number.
* 𝑃<.05 compared with the sham operated group;
^†𝑃<.05 compared with OVX control group;
^‡𝑃<.01 compared with OVX control group.