Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2011 (2011), Article ID 720853, 7 pages
http://dx.doi.org/10.1093/ecam/nep232
Original Article

A Valepotriate Fraction of Valeriana glechomifolia Shows Sedative and Anxiolytic Properties and Impairs Recognition But Not Aversive Memory in Mice

1Graduate Program in Cellular and Molecular Biology, Center for Biotechnology, Federal University of Rio Grande do Sul, 91501 970 Porto Alegre, RS, Brazil
2Laboratory of Molecular Neuropharmacology, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
3Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Brazil

Received 14 August 2009; Accepted 1 December 2009

Copyright © 2011 Natasha Maurmann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. S. Gooneratne, “Complementary and alternative medicine for sleep disturbances in older adults,” Clinics in Geriatric Medicine, vol. 24, no. 1, pp. 121–138, 2008. View at Publisher · View at Google Scholar · View at PubMed
  2. M. Blumenthal, “Valerian root,” in Herbal Medicine: Expanded Commission E Monographs, M. Blumenthal, A. Goldberg, and J. Brinckmann, Eds., pp. 394–400, Integrative Medicine Communications, Newton, Mass, USA, 2000. View at Google Scholar
  3. D. M. Taibi and C. A. Landis, “Valerian and other CAM botanicals in treatment of sleep disturbances,” in Complementary and Alternative Therapies and the Aging Population. An Evidence-Based Approach, R. R. Watson, Ed., pp. 57–81, Academic Press, Tucson, Ariz, USA, 2008. View at Google Scholar
  4. Sleep Disorders and CAM: At a Glace, “U.S. Department of Health and Human Services National Institutes of Health. National Center for Complementary and Alternative Medicine # 7. 2009,” November 2009, http://nccam.nih.gov/health/sleep/D437.pdf.
  5. R. Bos, H. J. Woerdenbag, F. M. S. Van Putten, H. Hendriks, and J. J. C. Scheffer, “Seasonal variation of the essential oil, valerenic acid and derivatives, and valepotriates in Valeriana officinalis roots and rhizomes, and the selection of plants suitable for phytomedicines,” Planta Medica, vol. 64, no. 2, pp. 143–147, 1998. View at Google Scholar
  6. M. Marder, H. Viola, C. Wasowski, S. Fernández, J. H. Medina, and A. C. Paladini, “6-methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS,” Pharmacology Biochemistry and Behavior, vol. 75, no. 3, pp. 537–545, 2003. View at Publisher · View at Google Scholar
  7. J. Veith, G. Schneider, B. Lemmer, and M. Willems, “The effect of degradation products of valepotriates on the motor activity of light-dark synchronized mice,” Planta Medica, vol. 52, pp. 179–183, 1986. View at Google Scholar
  8. B. M. Dietz, G. B. Mahady, G. F. Pauli, and N. R. Farnsworth, “Valerian extract and valerenic acid are partial agonists of the 5-HT 5a receptor in vitro,” Molecular Brain Research, vol. 138, no. 2, pp. 191–197, 2005. View at Publisher · View at Google Scholar · View at PubMed
  9. M. Hattesohl, B. Feistel, H. Sievers, R. Lehnfeld, M. Hegger, and H. Winterhoff, “Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties,” Phytomedicine, vol. 15, no. 1-2, pp. 2–15, 2008. View at Publisher · View at Google Scholar · View at PubMed
  10. A. L. Silva, S. B. Rech, and G. L. Von Poser, “Quantitative determination of valepotriates from Valeriana native to South Brazil,” Planta Medica, vol. 68, no. 6, pp. 570–572, 2002. View at Publisher · View at Google Scholar · View at PubMed
  11. C. M. B. de Carvalho, N. Maurmann, D. I. Luz, A. G. Fett-Neto, and S. B. Rech, “Control of development and valepotriate production by auxins in micropropagated Valeriana glechomifolia,” Plant Cell Reports, vol. 23, no. 4, pp. 251–255, 2004. View at Publisher · View at Google Scholar · View at PubMed
  12. N. Maurmann, C. M. B. De Carvalho, A. L. Silva, A. G. Fett-Neto, G. L. Von Poser, and S. B. Rech, “Valepotriates accumulation in callus, suspended cells and untransformed root cultures of Valeriana glechomifolia,” In Vitro Cellular and Developmental Biology—Plant, vol. 42, no. 1, pp. 50–53, 2006. View at Publisher · View at Google Scholar
  13. D. Russowski, N. Maurmann, S. B. Rech, and A. G. Fett-Neto, “Role of light and medium composition on growth and valepotriate contents in Valeriana glechomifolia whole plant liquid cultures,” Plant Cell, Tissue and Organ Culture, vol. 86, no. 2, pp. 211–218, 2006. View at Publisher · View at Google Scholar
  14. L. Salles, Phytochemical study and establishment of callus cultures of Valeriana glechomifolia Meyer (Estudo Fitoquímico e estabelecimento de culturas de calos de Valeriana glechomifolia Meyer), M.S. thesis, Pharmacy School, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil, 1999.
  15. J Hölzl and U Koch, “The compounds of Valeriana alliariifolia. I:1-β-acevaltrate, a new valepotriate (Über die Inhaltsstoffe von Valeriana alliariifolia. I: 1-β-acevaltratum, ein neues Valepotriate),” Planta Medica, vol. 50, p. 458, 1984. View at Google Scholar
  16. G. K. Reolon, L. M. Braga, M. Camassola et al., “Long-term memory for aversive training is impaired in Idua-/-mice, a genetic model of mucopolysaccharidosis type I,” Brain Research, vol. 1076, no. 1, pp. 225–230, 2006. View at Publisher · View at Google Scholar · View at PubMed
  17. R. G. Lister, “The use of a plus-maze to measure anxiety in the mouse,” Psychopharmacology, vol. 92, no. 2, pp. 180–185, 1987. View at Google Scholar
  18. K. Sichardt, Z. Vissiennon, U. Koetter, A. Brattström, and K. Nieber, “Modulation of postsynaptic potentials in rat cortical neurons by valerian extracts macerated with different alcohols: involvement of adenosine A 1- and GABAA-receptors,” Phytotherapy Research, vol. 21, no. 10, pp. 932–937, 2007. View at Publisher · View at Google Scholar · View at PubMed
  19. C.-S. Yuan, S. Mehendale, Y. Xiao, H. H. Aung, J.-T. Xie, and M. K. Ang-Lee, “The gammaminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity,” Anesthesia and Analgesia, vol. 98, no. 2, pp. 353–358, 2004. View at Google Scholar
  20. C. Nencini, F. Cavallo, A. Capasso et al., “Binding studies for serotoninergic, dopaminergic and noradrenergic receptors of Valeriana adscendens Trel. extracts,” Journal of Ethnopharmacology, vol. 108, no. 2, pp. 185–187, 2006. View at Publisher · View at Google Scholar · View at PubMed
  21. B. Schumacher, S. Scholle, J. Hölzl, N. Khudeir, S. Hess, and C. E. Müller, “Lignans isolated from Valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A1 adenosine receptors,” Journal of Natural Products, vol. 65, no. 10, pp. 1479–1485, 2002. View at Publisher · View at Google Scholar
  22. S. Gutierrez, M. K. Ang-Lee, D. J. Walker, and J. P. Zacny, “Assessing subjective and psychomotor effects of the herbal medication valerian in healthy volunteers,” Pharmacology Biochemistry and Behavior, vol. 78, no. 1, pp. 57–64, 2004. View at Publisher · View at Google Scholar · View at PubMed
  23. M. Rabbani, S. E. Sajjadi, and A. Mohammadi, “Evaluation of the anxiolytic effect of Nepeta persica Boiss. in mice,” Evidence-Based Complementary and Alternative Medicine, vol. 5, no. 2, pp. 181–186, 2008. View at Publisher · View at Google Scholar · View at PubMed
  24. Y. Djeridane, B. Lemmer, and Y. Touitou, “Diazepam affects both level and amplitude of rat locomotor activity rhythm but has no effect on core body temperature,” Chronobiology International, vol. 22, no. 6, pp. 975–985, 2005. View at Publisher · View at Google Scholar · View at PubMed
  25. J. L. McGaugh, “Dissociating learning and performance: drug and hormone enhancement of memory storage,” Brain Research Bulletin, vol. 23, no. 4-5, pp. 339–345, 1989. View at Publisher · View at Google Scholar
  26. M. G. Packard and L. A. Teather, “Double dissociation of hippocampal and dorsal-striatal memory systems by posttraining intracerebral injections of 2-amino-5-phosphonopentanoic acid,” Behavioral Neuroscience, vol. 111, no. 3, pp. 543–551, 1997. View at Publisher · View at Google Scholar
  27. R. Roesler, M. I. Kopschina, R. M. Rosa, J. A. P. Henriques, D. O. Souza, and G. Schwartsmann, “RC-3095, a bombesin/gastrin-releasing peptide receptor antagonist, impairs aversive but not recognition memory in rats,” European Journal of Pharmacology, vol. 486, no. 1, pp. 35–41, 2004. View at Publisher · View at Google Scholar