Anti-Inflammatory, Immunomodulatory, and Heme Oxygenase-1 Inhibitory Activities of Ravan Napas, a Formulation of Uighur Traditional Medicine, in a Rat Model of Allergic Asthma

Figure 5

Effect of Ravan Napas (RN) on IL-4, IL-5, INF-α, and INF-γ in serum of OVA-induced rat model of asthma. Blood was sampled and serum obtained 24 h after last OVA challenge. IL-4, IL-5, TNF-𝛼, and INF-𝛾 were analyzed by ELISA as described in the materials and methods section. Normal: rats sensitized with OVA and challenged with saline. Control: rats sensitized and challenged with OVA. DXM: OVA-sensitized and challenged rats treated with Dexamethasone (10 mg/kg). RN-1: OVA-sensitized and challenged rats treated with RN (0.25 g/kg/day). RN-2: OVA-sensitized and challenged rats treated with RN (0.5 g/kg/day). Data are expressed as mean±S.E.M., 𝑛=10 rats per group. ^▴▴▴𝑃<.01 versus Normal; ^∗∗∗𝑃<.01 versus Control.