Low-Frequency Electroacupuncture Improves Insulin Sensitivity in Obese Diabetic Mice through Activation of SIRT1/PGC-1𝛼 in Skeletal Muscle

Table 2

Animal characteristics and blood analyses.

Parameter (unit)	db/m (𝑛=8)	db/m+EA (𝑛=6)	db/db (𝑛=8)	db/db+EA (𝑛=8)
FBG (mg/dl)
0w	78.8 ± 2.8	75.2 ± 2.7	149.2 ± 13.8*	156 ± 21.6*
2w	72.5 ± 2.02	64.75 ± 2.06	406.5 ± 25.40*	365.5 ± 19.25*
4w	167 ± 19.7	141.8 ± 6.2	507.8 ± 88.5*	371 ± 32.3*
6w	114.5 ± 9.1	108.2 ± 5.9	466 ± 44.1*	330 ± 28.8^*†
8w	105.5 ± 5.07	83.5 ± 7.5	385 ± 34.15*	282 ± 31.5^*§
Insulin (ng/ml)
2w	0.53 ± 0.05	0.54 ± 0.03	3.69 ± 0.40*	2.05 ± 0.24^*†
8w	0.53 ± 0.05	0.54 ± 0.03	2.07 ± 0.31*	3.78 ± 0.53^*†
Body mass (g)
0w	26.46 ± 0.36	26.70 ± 0.28	37.90 ± 0.68*	37.59 ± 0.14*
2w	27.78 ± 0.45	26.32 ± 0.40	42.90 ± 0.56*	40.95 ± 0.82*
4w	28.35 ± 0.57	27.65 ± 0.34	45.31 ± 0.52*	43.80 ± 0.82*
6w	29.37 ± 0.80	28.79 ± 0.78	49.01 ± 0.60*	45.21 ± 1.16^*†
8w	30.7 ± 0.55	28.28 ± 0.46	49.12 ± 0.63*	44.95 ± 1.45^*†
Food intake (g/day)
0w	4.27 ± 0.13	4.81 ± 0.17	8.27 ± 0.72*	7.51 ± 1.02*
2w	3.94 ± 0.11	4.19 ± 0.09	7.93 ± 0.62*	7.41 ± 0.63*
4w	4.38 ± 0.12	3.91 ± 0.08	7.72 ± 0.35*	7.08 ± 0.38*
6w	3.97 ± 0.13	4.06 ± 0.12	7.27 ± 0.24*	6.45 ± 0.25^*†
8w	4.42 ± 0.13	4.41 ± 0.12	7.60 ± 0.23*	6.37 ± 0.30^*†
HbA1c (%)	3.56 ± 0.09	3.73 ± 0.12	7.55 ± 0.57*	7.03 ± 0.56*
FFA (𝜇Eq/L)	0.36 ± 0.03	0.36 ± 0.07	0.76 ± 0.04*	0.59 ± 0.03^*†
Triglycerides (mg/dL)	73.1 ± 14.2	66.3 ± 4.1	120.6 ± 21.9*	96.2 ± 8.3*
Cholesterol (mg/dL)	98.3 ± 3.9	90.4 ± 5.4	147.3 ± 15.15*	131.1 ± 2.8*
Corticosterone (ng/mL)	640.3 ± 137.8	773.7 ± 92.0	1154.7 ± 153.8*	1293.7 ± 81.8*
AUCg	902 ± 64.7	832 ± 24.6	2205 ± 156*	2069 ± 140*

Data are mean ± SE. ^∗𝑃<.05 versus db/m and db/m+EA; ^†𝑃<.05 versus db/db; ^§𝑃<.01 versus db/db. HbA1c: glycosylated hemoglobin A1c, FFA: free fatty acids, AUCg: area under the IPGTT (intraperitoneal glucose tolerance test) curve.