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Evidence-Based Complementary and Alternative Medicine
Volume 2011 (2011), Article ID 745262, 7 pages
http://dx.doi.org/10.1155/2011/745262
Research Article

Quercetin and Bornyl Acetate Regulate T-Lymphocyte Subsets and INF-γ/IL-4 Ratio In Utero in Pregnant Mice

1College of Traditional Chinese Veterinary Medicine, Agricultural University of Hebei, Baoding 071001, China
2College of Animal Science and Veterinary Medicine, Agricultural University of Hebei, Baoding 071001, China

Received 25 April 2010; Revised 21 June 2010; Accepted 10 September 2010

Copyright © 2011 Xiaodan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The objective of this study is to investigate the antiabortive effects of Quercetin and Bornvl Acetate and their immunological modulation at maternal-fetal interface. Lipopolysaccharide (LPS) was injected via tail vein to induce abortion in mice which received Quercetin and Bornvl Acetate at days 4–7 of gestation. Uterine CD4+/CD8+ T lymphocytes and IFN-γ/IL-4 of each group (n=10) were detected by immunohistochemistry and enzyme-linked immunosorbent assay, respectively. The ratio of CD4+/CD8+ increased significantly (P<.01) in the uterus of LPS-induced abortion mice. In the Quercetin and Bornvl Acetate pretreated mice followed by LPS administration, the ratio of CD4+/CD8+ dropped to 0.562±0.021, lower than that of LPS-abortion group (P<.01). The mean value of IFN-γ/IL-4 in LPS-treated mice was 0.310±0.066, higher than that of Quercetin and Bornyl Acetate group. The results indicate that Quercetin and Bornyl Acetate have an antiabortive effect through modulation of immunological balance at maternal-fetal interface.