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Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 748283, 8 pages
http://dx.doi.org/10.1093/ecam/nep112
Original Article

Aqueous Extract of Brazilian Green Propolis: Primary Components, Evaluation of Inflammation and Wound Healing by Using Subcutaneous Implanted Sponges

1Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais-UFMG, Belo Horizonte, Brazil
2CEBRID—Department of Psychobiology, UNIFESP, R. Botucatu, 862, Biomedical Sciences, Brazil
3Department of Botany, Biosciences Institute, University of São Paulo, R. do Matão 277, São Paulo, Brazil
4Department of Physiology, Institute of Biological Sciences, Federal University of Minas Gerais-UFMG, Avenida Antônio Carlos, 6627, Pampulha, CEP 31.270-901, Belo Horizonte, Minas Gerais, Brazil

Received 4 December 2008; Accepted 17 July 2009

Copyright © 2011 Sandra Aparecida Lima de Moura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. EMAF Bastos, M Simone, DM Jorge, AEE Soares, E Ademilson, and M Spivak, “In vitro study of the antimicrobial activity of Brazilian propolis against Paenibacillus larvae,” J Invertebr Pathol, vol. 97, pp. 273–81, 2008. View at Google Scholar
  2. N Paulino, SRL Abreu, Y Uto, D Koyama, H Nagasawa, H Hori et al., “Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis,” Eur J Pharmacol, vol. 587, pp. 296–301, 2008. View at Google Scholar
  3. WM Wu, L Lu, Y Long, T Wang, L Liu, Q Chen et al., “Free radical scavenging and antioxidative activities of caffeic acid phenethyl ester (CAPE) and its related compounds in solution and membranes: a structure-activity insight,” Food Chem, vol. 105, pp. 107–15, 2007. View at Google Scholar
  4. AH Banskota, Y Tezuka, IK Adnyana, E Ishii, K Midorikawa, K Matsushige et al., “Hepatoprotective and anti-Helicobacter pylori activities of constituents from Brazilian propolis,” Phytomedicine, vol. 8, pp. 16–23, 2001. View at Google Scholar
  5. N Orsolic and I Basic, “Water-soluble derivative of propolis and its polyphenolic compounds enhance tumoricidal activity of macrophages,” J Ethnopharmacol, vol. 102, pp. 37–45, 2005. View at Google Scholar
  6. T Matsuno, SK Jung, Y Matsumoto, M Saito, and J Morikawa, “Preferential cytotoxicity to tumor cells of 3,5-diprenyl-4-hydroxycinnamic acid (artepillin C) isolated from propolis,” Anticancer Res, vol. 17, pp. 565–568, 1997. View at Google Scholar
  7. MP De Barros, JPB Sousa, JK Bastos, and SF de Andrade, “Effect of Brazilian green propolis on experimental gastric ulcers in rats,” J Ethnopharmacol, vol. 110, pp. 567–71, 2007. View at Google Scholar
  8. G Negri, MLF Salatino, and A Salatino, “‘Green propolis’: unreported constituents and a novel compound from chloroform extracts,” J Apicl Res, vol. 42, pp. 39–41, 2003. View at Google Scholar
  9. JH Zhou, Y Li, J Zhao, XF Xue, LM Wu, and F Chen, “Geographical traceability of propolis by high-performance liquid-chromatography fingerprints,” Food Chem, vol. 108, pp. 749–59, 2008. View at Google Scholar
  10. C Medana, F Carbone, R Aigotti, G Appendino, and C Baiocchi, “Selective analysis of phenolic compounds in propolis by HPLC-MS/MS,” Phytochem Anal, vol. 19, pp. 32–9, 2008. View at Google Scholar
  11. A Salatino, EW Teixeira, G Negri, and D Message, “Origin and chemical variation of Brazilian propolis,” eCAM, vol. 2, pp. 33–8, 2005. View at Google Scholar
  12. J Hernandez, FM Goycoolea, J Quintero, A Acosta, M Castaneda, Z Dominguez et al., “Sonoran Propolis: chemical composition and antiproliferative activity on cancer cell lines,” Planta Med, vol. 73, pp. 1469–74, 2007. View at Google Scholar
  13. M Shimazawa, S Chikamatsu, N Morimoto, S Mishima, H Nagai, and H Hara, “Neuroprotection by Brazilian green propolis against in vitro and in vivo ischemic neuronal damage,” eCAM, vol. 2, pp. 201–7, 2005. View at Google Scholar
  14. AH Banskota, Y Tezuka, and S Kadota, “Recent progress in pharmacological research of propolis,” Phytother Res, vol. 115, pp. 561–71, 2001. View at Google Scholar
  15. T Matsui, S Ebuchi, T Fujise et al., “Strong antihyperglycemic effects of water-soluble fraction of Brazilian propolis and its bioactive constituent, 3, 4, 5-tri-o-caffeoylquinic acid,” Biol Pharm Bull, vol. 27, pp. 1797–803, 2004. View at Google Scholar
  16. EW Teixeira, G Negri, RMSA Meira, D Message, and A Salatino, “Plant origin of green propolis: bee behavior, plant anatomy and chemistry,” eCAM, vol. 1, pp. 85–92, 2005. View at Google Scholar
  17. Y Nakajima, M Shimazawa, S Mishima, and H Hara, “Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions,” Life Sci, vol. 80, pp. 370–7, 2007. View at Google Scholar
  18. SP Andrade, RDP Machado, AS Teixeira, and WT Beraldo, “Sponge-induced angiogenesis in mice and the pharmacological reactivity of the neovasculature quantitated by a fluorimetric method,” Microvasc Res, vol. 54, pp. 253–61, 1997. View at Google Scholar
  19. PP Campos, SP Andrade, L Moro, MAND Ferreira, and AC Vasconcelos, “Cellular proliferation, differentiation and apoptosis in polyether-polyurethane sponge implant model in model in mice,” Histol Histopathol, vol. 21, pp. 1263–70, 2006. View at Google Scholar
  20. AD Bradshaw, MJ Reed, JG Carbon, E Pinney, RA Brekken, and H Sage, “Increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges in SPARC-null mice,” Wound Repair Regen, vol. 9, pp. 522–30, 2001. View at Google Scholar
  21. NB Fang, SG Yu, and RL Prior, “LC/MS/MS characterization of phenolic constituents in dried plums,” J Agric Food Chem, vol. 50, pp. 3579–85, 2002. View at Google Scholar
  22. Y Matsui, S Nakamura, N Kondou, Y Takasu, R Ochiai, and Y Masukawa, “Liquid chromatography-electrospray ionization-tandem mass spectrometry for simultaneous analysis of chlorogenic acids and their metabolites in human plasma,” J Chromatogr B, vol. 858, pp. 96–105, 2007. View at Google Scholar
  23. LZ Lin and JM Harnly, “Identification of hydroxycinnamoylquinic acids of arnica flowers and burdock roots using a standardized LC-DAD-ESI/MS profiling method,” J Agric Food Chem, vol. 56, pp. 10105–14, 2008. View at Google Scholar
  24. LCU Junqueira, W Cossermeli, and R Brentani, “Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections,” Histochem J, vol. 11, pp. 447–55, 1979. View at Google Scholar
  25. DG Greenhalgh, “The role of apoptosis in wound healing,” J Biochem Cell Biol, vol. 30, pp. 1019–30, 1998. View at Google Scholar
  26. MN Clifford, S Marks, S Knight, and N Kuhnert, “Characterization by LC-MSn of four new classes of p-coumaric acid-containing diacyl chlorogenic acids in green coffee beans,” J Agric Food Chem, vol. 54, pp. 4095–101, 2006. View at Google Scholar
  27. EL Ghisalbert, “Propolis: a review,” Bee World, vol. 60, pp. 59–84, 1979. View at Google Scholar
  28. MT Khayyal, MA El-Ghazaly, and AS El-khatib, “Mechanisms involved in the anti-inflammatory effect of propolis extract,” Drugs Under Exp Clin Res, vol. 19, pp. 192–203, 1993. View at Google Scholar
  29. F Hu, HR Hepburn, Y Li, M Chen, SE Radloff, and S Daya, “Effects of ethanol and water extracts of propolis (bee glue) on acute inflammatory animal models,” J Ethnopharmacol, vol. 100, pp. 276–83, 2005. View at Google Scholar
  30. G Serarslan, E Altuğ, T Kontas, E Atik, and G Avci, “Caffeic acid phenethyl ester accelerates cutaneous wound healing in a rat model and decreases oxidative stress,” Clin Exp Dermatol, vol. 32, pp. 709–15, 2007. View at Google Scholar
  31. E Sehn, L Hernandes, SL Franco, CC Gonçalves, and ML Baesso, “Dynamics of reepithelialisation and penetration rate of a bee propolis formulation during cutaneous wounds healing,” Anal Chim Acta, vol. 635, pp. 115–20, 2009. View at Google Scholar
  32. TR Kyriakides, YH Zhu, Z Yang, G Huynh, and P Bornstein, “Altered extracelular matrix remodeling and angiogenesis in sponge granulomas of thrombospondin 2-null mice,” Am J Pathol, vol. 159, pp. 1255–62, 2001. View at Google Scholar
  33. SR Opalenik and JM Davidson, “Fibroblast differentiation of bone marrow-derived cells during wound repair,” FASEB J, vol. 11, pp. 1561–3, 2005. View at Google Scholar
  34. SS Kilicoglu, B Kilicoglu, and E Erdemli, “Ultrastructural view of colon anastomosis under propolis effect by transmission electron microscopy,” World J Gastroenterol, vol. 30, pp. 4763–70, 2008. View at Google Scholar
  35. TR Wilgus, Y Vodovoltz, E Vittadini, EA Clubbs, and TM Oberyszyn, “Reduction of scar formation in full-thickness wounds with topical celecoxib treatment,” Wound Repair Regen, vol. 11, pp. 25–34, 2003. View at Google Scholar