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Evidence-Based Complementary and Alternative Medicine
Volume 2011 (2011), Article ID 761859, 10 pages
http://dx.doi.org/10.1093/ecam/nep078
Research Article

KIOM-79, an Inhibitor of AGEs–Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats

Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea

Received 24 March 2009; Accepted 28 May 2009

Copyright © 2011 Young Sook Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Brownlee, “The pathobiology of diabetic complications: a unifying mechanism,” Diabetes, vol. 54, no. 6, pp. 1615–1625, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. A. G. Huebschmann, H. Vlassara, J. G. Regensteiner, and J. Reusch, “Diabetes and advanced glycoxidation end products,” Annual Review of Diabetes, pp. 51–63, 2007. View at Google Scholar
  3. N. L. Alderson, M. E. Chachich, N. N. Youssef et al., “The AGE inhibitor pyridoxamine inhibits lipemia and development of renal and vascular disease in Zucker obese rats,” Kidney International, vol. 63, no. 6, pp. 2123–2133, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. J. L. Figarola, S. Scott, S. Loera et al., “Lr-90 a new advanced glycation endproduct inhibitor prevents progression of diabetic nephropathy in streptozotocin-diabetic rats,” Diabetologia, vol. 46, no. 8, pp. 1140–1152, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Peppa, H. Brem, W. Cai et al., “Prevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711),” American Journal of Nephrology, vol. 26, no. 5, pp. 430–436, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. P. N. Chander, O. Gealekman, S. V. Brodsky et al., “Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen,” Journal of the American Society of Nephrology, vol. 15, no. 9, pp. 2391–2403, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. T. M. Coimbra, U. Janssen, H. J. Gröne et al., “Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes,” Kidney International, vol. 57, no. 1, pp. 167–182, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. W. L. Li, H. C. Zheng, J. Bukuru, and N. De Kimpe, “Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus,” Journal of Ethnopharmacology, vol. 92, no. 1, pp. 1–21, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Hur, in Donguibogam Parallel Version, p. 1979, Bupin, Seoul, Korea, 1999.
  10. Y. J. Jeon, M. H. Li, K. Y. Lee et al., “KIOM-79 inhibits LPS-induced iNOS gene expression by blocking NF-κB/Rel and p38 kinase activation in murine macrophages,” Journal of Ethnopharmacology, vol. 108, no. 1, pp. 38–45, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. S. Kim, Y. M. Lee, C.-S. Kim, E. J. Sohn, D. S. Jang, and J. S. Kim, “Inhibitory effect of KIOM-79, a new herbal prescription, on AGEs formation and expression of type IV collagen and TGF-β1 in STZ-induced diabetic rats,” Korean Journal of Pharmacogn, vol. 37, pp. 103–109, 2006. View at Google Scholar
  12. C.-S. Kim, E. J. Sohn, Y. S. Kim et al., “Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats,” Journal of Ethnopharmacology, vol. 111, no. 2, pp. 240–247, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Vasan, K. Netram, X. Zhang, D. Wagle, R. Ramdass, and D. Shih, “Identification of new inhibitors of AGE-protein crosslinking using a novel ELISA (Abstract),” Diabetes, vol. 45, p. A258, 1996. View at Google Scholar
  14. S. Vasan, X. Zhang, X. Zhang et al., “An agent cleaving glucose-derived protein crosslinks in vitro and in vivo,” Nature, vol. 382, no. 6588, pp. 275–278, 1996. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. S. Kim, D. H. Jung, N. H. Kim et al., “KIOM-79 inhibits high glucose or AGEs-induced VEGF expression in human retinal pigment epithelial cells,” Journal of Ethnopharmacology, vol. 112, no. 1, pp. 166–172, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. Y.-S. Kim, Z.-G. Xu, M. A. Reddy et al., “Novel interactions between TGF-β1 actions and the 12/15-lipoxygenase pathway in mesangial cells,” Journal of the American Society of Nephrology, vol. 16, no. 2, pp. 352–362, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Mundel, H. W. Heid, T. M. Mundel, M. Krüger, J. Reiser, and W. Kriz, “Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes,” Journal of Cell Biology, vol. 139, no. 1, pp. 193–204, 1997. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Schiffer, P. Mundel, A. S. Shaw, and E. P. Böttinger, “A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis,” The Journal of Biological Chemistry, vol. 279, pp. 37004–37012, 2004. View at Google Scholar
  19. K. A. Kang, K. H. Lee, S. Y. Kim, H. S. Kim, J. S. Kim, and J. W. Hyun, “Cytoprotective effects of KIOM-79 on streptozotocin induced cell damage by inhibiting ERK and AP-1,” Biological and Pharmaceutical Bulletin, vol. 30, no. 5, pp. 852–858, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. J. T. Paul, “Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation end products,” Archives of Biochemistry and Biophysics, vol. 419, pp. 31–40, 2003. View at Google Scholar
  21. S. Padival and R. H. Nagaraj, “Pyridoxamine inhibits maillard reactions in diabetic rat lenses,” Ophthalmic Research, vol. 38, no. 5, pp. 294–302, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Tanimoto, T. Gohda, S. Kaneko et al., “Effect of pyridoxamine (K-163), an inhibitor of advanced glycation end products, on type 2 diabetic nephropathy in KK-Ay/Ta mice,” Metabolism, vol. 56, no. 2, pp. 160–167, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Odetti, C. Pesce, N. Traverso et al., “Comparative trial of N-acetyl-cysteine, taurine, and oxerutin on skin and kidney damage in long-term experimental diabetes,” Diabetes, vol. 52, no. 2, pp. 499–505, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. B. Manuely Keenoy, J. Vertommen, and I. De Leeuw, “The effect of flavonoid treatment on the glycation and antioxidant status in type 1 diabetic patients,” Diabetes, Nutrition and Metabolism, vol. 12, pp. 256–263, 1999. View at Google Scholar
  25. D. L. Price, P. M. Rhett, S. R. Thorpe, and J. W. Baynes, “Chelating activity of advanced glycation end-product inhibitors,” Journal of Biological Chemistry, vol. 276, no. 52, pp. 48967–48972, 2001. View at Publisher · View at Google Scholar · View at Scopus
  26. J. L. Wilkinson-Berka, D. J. Kelly, S. M. Koerner et al., “ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat,” Diabetes, vol. 51, no. 11, pp. 3283–3289, 2002. View at Google Scholar · View at Scopus
  27. S. Hoshi, Y. Shu, F. Yoshida et al., “Podocyte injury promotes progressive nephropathy in zucker diabetic fatty rats,” Laboratory Investigation, vol. 82, no. 1, pp. 25–35, 2002. View at Google Scholar · View at Scopus
  28. K. Susztak, A. C. Raff, M. Schiffer, and E. P. Böttinger, “Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy,” Diabetes, vol. 55, pp. 225–233, 2006. View at Google Scholar
  29. Y. S. Kim, N. H. Kim, D. H. Jung, E. J. Sohn, Y. M. Lee, D. S. Jang et al., “Effect of KIOM-79 on expression of TGF-beta2 in human lens epithelial cells under hyperglycemic conditions and in an in vitro rat model of cataract (Abstract),” Diabetes, vol. 57, p. A114, 2008. View at Google Scholar
  30. J. H. Kim, C.-S. Kim, E. J. Sohn, O. S. Kim, Y. M. Lee, D. S. Jang et al., “Effects of KIOM-79 on diabetic retinopathy in Zucker diabetic fatty rat (Abstract),” Diabetes, vol. 57, p. A572, 2008. View at Google Scholar