KIOM-79, an Inhibitor of AGEs–Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats
Table 2
Plasma chemistry of experimental rats.
ZL
ZF
ZF + AG
ZF + KIOM-79
AST (U/l)
121.79 ± 16.10
177.70 ± 49.86
124.03 ± 16.09
137.61 ± 34.66
ALT (U/l)
48.49 ± 6.78
116.07 ± 17.23***
89.60 ± 26.12
105.76 ± 54.35
Total cholesterol (mg/dl)
100.61 ± 7.27
254.72 ± 18.13***
229.28 ± 43.65
228.33 ± 21.69
HDL-Chol (mg/dl)
34.59 ± 2.13
72.72 ± 6.88***
70.53 ± 15.77
68.24 ± 10.32
LDL-Chol (mg/dl)
8.64 ± 0.81
34.63 ± 6.47***
26.98 ± 9.84*
26.27 ± 7.88*
Triglyceride (mg/dl)
93.09 ± 24.10
1112.60 ± 330.70***
817.12 ± 294.08*
881.04 ± 335.54*
FFA (uEq/l)
896.29 ± 185.25
1775.83 ± 331.57
1677.67 ± 239.19
1224.14 ± 172.37**
HbA1c (%)
3.71 ± 0.11
7.78 ± 1.19***
6.94 ± 1.07*
7.07 ± 0.61*
ZL: normal lean rat; ZF: ZDF rat; ZF + AG: ZDF rat treated with AG (50 mg/ml); ZF + KIOM-79: ZDF rat treated with KIOM-79 (50 mg/kg). All data were expressed as mean ± SD.
***
versus ZL group; * versus ZF group; ** versus ZF group.
