Anticancer Potential of Aqueous Ethanol Seed Extract of Ziziphus mauritiana against Cancer Cell Lines and Ehrlich Ascites Carcinoma

Table 1

Effect of ZMS treatment on EAC-bearing mice.

Parameters	Treatment of different groups
	Control	EAC	EAC + 5FU	EAC + ZMS	EAC + ZMS	EAC + ZMS	EAC + ZMS
	Dose (mg/kg b.wt.)		20	100	200	400	800
Hb content (mg/dl)	13  ±  0.5	9.5  ±  0.73^a	13.1  ±  0.4^b	11.24  ±  0.67^b	11.59  ±  0.6^b	12.4  ±  0.81^b	12.2  ±  0.45^b
WBC (cells/mL × 10^6)	7.17  ±  0.11	15.6  ±  0.64^a	7.73  ±  0.68^a	12.1  ±  0.75^b	9.4  ±  0.83^b	9.2  ±  1.26^b	8.5  ±  0.40^b
RBC (cells/mL × 10^6)	5.33  ±  0.45	3.5  ±  0.41^a	5.2  ±  0.11^b	4.2  ±  0.55^b	4.3  ±  0.35^b	4.9  ±  0.15^b	5.0  ±  0.12^b
Tumor Volume (mL)	—	8.3  ±  0.79	0.7  ±  0.20^b	7.6  ±  0.94^b	5.4  ±  0.96^b	4.5  ±  1.04^b	2.1  ±  0.51^b
Viable tumor Cell Count (×10^7)	—	283.02  ±  1.63	11.17  ±  0.96^b	186.12  ±  1.57^b	146.27  ±  1.43^b	109.57  ±  1.08^b	69.59  ±  1.62^b
Mean Survival time (Days)	—	20  ±  1.41	39  ±  0.81^b	23  ±  1.53^b	26  ±  1.73^b	30  ±  0.81^b	34  ±  1.63
Tumor inhibition (%)	—		96.11  ±  0.73	25.67  ±  1.09	39.78  ±  2.55	57.54  ±  1.03	75.42  ±  0.96
Increase in life span (%)	—		95	15	30	50	70

The results are presented as Mean  ±  S.E.M. (𝑛=10). ^a𝑃<.001 in comparison to normal group; ^b𝑃<.05 in comparison to EAC control group.