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Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 783413, 7 pages
http://dx.doi.org/10.1093/ecam/nep221
Original Article

Evaluation of In Vitro Uterotonic Activities of Fruit Extracts of Ficus asperifolia in Rats

1Animal Physiology and Phytopharmacology Laboratory, Department of Animal Biology, Faculty of Science, University of Dschang, Po Box 377 Dschang, Cameroon
2Department of Chemistry, University of Dschang, Box 67 Dschang, Cameroon

Received 10 February 2009; Accepted 1 December 2009

Copyright © 2011 Pierre Watcho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. “Population Reference Bureau Staff Transitions in world population,” Population Bulletin, vol. 59, pp. 1–43, 2004.
  2. World Population Data Sheet of the Population Reference Bureau, Population Reference Bureau, Washington, DC, USA, 2004.
  3. R. Sitruk-Ware, “Contraception: an international perspective,” Contraception, vol. 73, no. 3, pp. 215–222, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. S. R. Srivastava, G. Keshri, B. Bhargavan, C. Singh, and M. M. Singh, “Pregnancy interceptive activity of the roots of Calotropis gigantea Linn. in rats,” Contraception, vol. 75, no. 4, pp. 318–322, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Vasudeva and S. K. Sharma, “Post-coital antifertility activity of Hibiscus rosa-sinensis Linn. roots,” Evidence-Based Complementary and Alternative Medicine, vol. 5, no. 1, pp. 91–94, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Ganguly, M. Kr.Borthakur, N. Devi, and R. Mahanta, “Antifertility activity of the methanolic leaf extract of Cissampelos pareira in female albino mice,” Journal of Ethnopharmacology, vol. 111, no. 3, pp. 688–691, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. J. D. Adams Jr. and C. Garcia, “Women's health among the Chumash,” Evidence-Based Complementary and Alternative Medicine, vol. 3, no. 1, pp. 125–131, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. J. C. Adjanohoun, N. Aboubaker, K. Dramane, M. E. Ebot, J. A. Ekpere, and E. G. Enow-Orock, “Traditional medicine and pharmacopoeia,” in Contribution to Ethnobotanical and Floristic Studies in Cameroon, pp. 301–325, OUA/STRC, Lagos, Nigeria, 1996. View at Google Scholar
  9. A. Soforowa, Plantes Médicinales et Médecine Traditionnelle d'Afrique, Edition Karthala, Paris, France, 1996.
  10. M. O. Uguru, F. K. Okwuasaba, E. E. Ekwenchi, and V. E. Uguru, “Uterotonic properties of the methanol extract of Monechma ciliatum,” Journal of Ethnopharmacology, vol. 62, no. 3, pp. 203–208, 1998. View at Publisher · View at Google Scholar · View at Scopus
  11. D. J. H. Veale, I. Havlik, D. W. Oliver, and T. G. Dekker, “Pharmacological effects of Agapanthus africanus on the isolated rat uterus,” Journal of Ethnopharmacology, vol. 66, no. 3, pp. 257–262, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. H. O. Vongtau, S. Amos, L. Binda et al., “Pharmacological effects of the aqueous extract of Neorautanenia mitis in rodents,” Journal of Ethnopharmacology, vol. 72, no. 1-2, pp. 207–214, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. A. M. Salah, J. Gathumb, W. Vierling, and H. Wagne, “Estrogenic and cholinergic properties of the methanol extract of Ruellia praetermissa Sceinf. ex. Lindau (Acanthaceae) in female rats,” Phytomedicine, vol. 9, pp. 52–55, 2002. View at Google Scholar
  14. J. Bruneton, Pharmacognosy—Phytochemistry of Medicinal Plants, Tech & Doc-Lavoisier, Paris, France, 1999.
  15. K. R. Markham, Techniques of Flavonoid Identification, Academic Press, Amsterdam, The Netherlands, 1982.
  16. W. Klyne, La Chimie des Stéroïdes, Gauthier-Villars, 1970.
  17. K. Hostettmann, M. Hostettmann, and A. Marston, “Saponins,” in Methods in Plants Biochemistry, P. M. Dey and J. B. Harbonne, Eds., pp. 435–471, Academic Press, New York, NY, USA, 1991. View at Google Scholar
  18. F. G. Varol, M. Hadjiconstantinou, F. P. Zuspan, and N. H. Neff, “Pharmacological characterization of the muscarinic receptors mediating phosphoinositide hydrolysis in rat myometrium,” Journal of Pharmacology and Experimental Therapeutics, vol. 249, no. 1, pp. 11–15, 1989. View at Google Scholar · View at Scopus
  19. H. N. Doods, K. D. Willim, H. W. G. M. Boddeke, and M. Entzeroth, “Characterization of muscarinic receptors in guinea-pig uterus,” European Journal of Pharmacology, vol. 250, no. 2, pp. 223–230, 1993. View at Publisher · View at Google Scholar · View at Scopus
  20. I. Martinez-Mir, J. Herrero, L. Estan, F. J. Morales-Olivas, and E. Rubio, “Effect of histamine on the longitudinal and circular muscle of the oestrogen dominated rat uterus,” Agents and Actions, vol. 39, no. 1-2, pp. 1–5, 1993. View at Google Scholar · View at Scopus
  21. W. Y. Chan, D. L. Chen, and M. Manning, “Oxytocic receptor subtypes in the pregnant rat myometrium and deciduas: pharmacological differentiations,” Endocrinology, vol. 132, pp. 1381–1386, 1993. View at Google Scholar
  22. R. A. Coleman, W. L. Smith, and S. Narumiya, “International union of pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes,” Pharmacological Reviews, vol. 46, no. 2, pp. 205–229, 1994. View at Google Scholar · View at Scopus
  23. M. Shi, L. Chang, and G. He, “Stimulating action of Carthamus tinctorius L., Angelica sinensis (Oliv.) Diels and Leonurus sibiricus L. on the uterus,” Zhongguo Zhong Yao Za Zhi, vol. 20, no. 3, pp. 173–192, 1995. View at Google Scholar · View at Scopus
  24. D. J. H. Veale, D. W. Oliver, and I. Havlik, “The effects of herbal oxytocics on the isolated “stripped” myometrium model,” Life Sciences, vol. 67, no. 11, pp. 1381–1388, 2000. View at Publisher · View at Google Scholar · View at Scopus
  25. A. E. Eno and E. H. Itam, “Stimulation of autonomic cholinoceptors in the rat uterus by a crude extract from eleophorbia drupifera leaves,” Pharmaceutical Biology, vol. 36, no. 2, pp. 97–102, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Y. Dawood, “Pharmacologic stimulation of uterine contraction,” Seminars in Perinatology, vol. 19, no. 1, pp. 73–83, 1995. View at Publisher · View at Google Scholar · View at Scopus
  27. A. A. Lanzafame, A. Christopoulos, and F. Mitchelson, “Cellular signaling mechanisms for muscarinic acetylcholine receptors,” Receptors and Channels, vol. 9, no. 4, pp. 241–260, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. J. M. Willets, A. H. Taylor, H. Shaw, J. C. Konje, and R. A. J. Challiss, “Selective regulation of H1 histamine receptor signaling by G protein-coupled receptor kinase 2 in uterine smooth muscle cells,” Molecular Endocrinology, vol. 22, no. 8, pp. 1893–1907, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Govind, M. O. Ravi, L. Vijai, P. Kartikay, and M. S. Man, “Contraceptive and hormonal properties of the stem bark of Dysoxylum binectariferum in rat and docking analysis of rohitukine, the alkaloid isolated from active chloroform soluble fraction,” Contraception, vol. 76, pp. 400–407, 2007. View at Google Scholar
  30. L. Guo, J. Su, B. W. Deng, Z. Y. Yu, L. P. Kang, and Z. H. Zhao, “Active pharmaceutical ingredients and mechanisms underlying phasic myometrial contractions stimulated with the saponin extract from Paris polyphylla Sm. var. yunnanensis used for abnormal uterine bleeding,” Human Reproduction, vol. 23, pp. 964–971, 2008. View at Google Scholar
  31. M. T. Yakubu and B. B. Bukoye, “Abortifacient potentials of the aqueous extract of Bambusa vulgaris leaves in pregnant Dutch rabbits,” Contraception, vol. 80, no. 3, pp. 308–313, 2009. View at Publisher · View at Google Scholar · View at Scopus