Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2011 (2011), Article ID 802937, 8 pages
http://dx.doi.org/10.1155/2011/802937
Research Article

Hemidesmus indicus and Hibiscus rosa-sinensis Affect Ischemia Reperfusion Injury in Isolated Rat Hearts

1Institute for Heart Research, Centre of Excellence for Cardiovascular Research, Slovak Academy of Sciences, 840 05 Bratislava, Slovakia
2Pharmacy Department, Faculty of Technology & Engineering, M. S. University of Baroda, 390 001 Vadodara, Gujarat, India

Received 9 June 2009; Revised 29 December 2009; Accepted 10 July 2010

Copyright © 2011 Vinoth Kumar Megraj Khandelwal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Anjaria, M. Parabia, G. Bhatt, and R. Khamar, Nature Heals, a Glossary of Selected Indigenous Medicinal Plants of India, SRISTI Innovations, Ahmedabad, India, 2002.
  2. A. H. Rajasab and I. Mahamad, “Documentation of folk knowledge on edible wild plants of north Karnataka,” Indian Journal of Traditional Knowledge, vol. 3, pp. 419–429, 2004. View at Google Scholar
  3. S. Murshed, B. Rokeya, N. Nahar et al., “Hypoglycemic and hypolipidemic effect of Hemidesmus indicus root on diabetic model rats,” Diabetes Research, vol. 39, pp. 15–23, 2005. View at Google Scholar
  4. K. N. Bopanna, N. Bhagyalakshmi, S. P. Rathod, R. Balaraman, and J. Kannan, “Cell culture derived Hemidesmus indicus in the prevention of hypercholesterolemia in normal and hyperlipidemic rats,” Indian Journal of Pharmacology, vol. 29, no. 2, pp. 105–109, 1997. View at Google Scholar · View at Scopus
  5. N. K. Mary, C. R. Achuthan, B. H. Babu, and J. Padikkala, “In vitro antioxidant and antithrombotic activity of Hemidesmus indicus (L) R.Br,” Journal of Ethnopharmacology, vol. 87, no. 2-3, pp. 187–191, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. I. Lampronti, M. T. H. Khan, M. Borgatti, N. Bianchi, and R. Gambari, “Inhibitory effects of Bangladeshi medicinal plant extracts on interactions between transcription factors and target DNA sequences,” Evidence-Based Complementary and Alternative Medicine, vol. 5, no. 3, pp. 303–312, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Anoop and M. Jegadeesan, “Biochemical studies on the anti-ulcerogenic potential of Hemidesmus indicus R.Br. var. indicus,” Journal of Ethnopharmacology, vol. 84, no. 2-3, pp. 149–156, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Prabakan, R. Anandan, and T. Devaki, “Protective effect of Hemidesmus indicus against rifampicin and isoniazid-induced hepatotoxicity in rats,” Fitoterapia, vol. 71, no. 1, pp. 55–59, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. M. S. Kotnis, P. Patel, S. N. Menon, and R. T. Sane, “Renoprotective effect of Hemidesmus indicus, a herbal drug used in gentamicin-induced renal toxicity,” Nephrology, vol. 9, no. 3, pp. 142–152, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. M. I. Alam, B. Auddy, and A. Gomes, “Viper venom neutralization by Indian medicinal plant (Hemidesmus indicus and Pluchea indica) root extracts,” Phytotherapy Research, vol. 10, no. 1, pp. 58–61, 1996. View at Publisher · View at Google Scholar · View at Scopus
  11. R. N. Chopra, S. L. Nayar, and I. C. Chopra, Glossary of Indian Medicinal Plants, National Institute of Science Communication, New Delhi, India, 1956.
  12. S. Facciola, Cornucopia II: A Source Book of Edible Plants, Kampong Publications, Vista, Calif, USA, 1998.
  13. G. Kunkel, Plants For Human Consumption: An Annotated Checklist of the Edible Phanerogams and Ferns, Koeltz Scientific Books, 1984.
  14. A. B. Cribb and J. W. Cribb, Wild Food in Australia, Fontana, Sydney, Australia, 1982.
  15. J. A. Vinson, Y. A. Dabbagh, M. M. Serry, and J. Jang, “Plant flavonoids, especially tea flavonols, are powerful antioxidants using an in vitro oxidation model for heart disease,” in Cure of Heart Diseases with Ayurvedic Drugs, U. D. Sharma, Ed., pp. 95–96, Sachitra Ayurved, 1994. View at Google Scholar
  16. A. Sachdewa and L. D. Khemani, “Effect of Hibiscus rosa sinensis Linn. ethanol flower extract on blood glucose and lipid profile in streptozotocin induced diabetes in rats,” Journal of Ethnopharmacology, vol. 89, no. 1, pp. 61–66, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. S. D. Kholkute and K. N. Udupa, “Antiestrogenic activity of Hibiscus rosa sinensis Linn. flowers,” Indian Journal of Experimental Biology, vol. 14, no. 2, pp. 175–176, 1976. View at Google Scholar · View at Scopus
  18. D. R. K. Murthy, C. Madhusudana Reddy, and S. B. Patil, “Effect of benzene extract of Hibiscus rosa sinensis on the estrous cycle and ovarian activity in albino mice,” Biological and Pharmaceutical Bulletin, vol. 20, no. 7, pp. 756–758, 1997. View at Google Scholar · View at Scopus
  19. N. Vasudeva and S. K. Sharma, “Post-coital antifertility activity of Hibiscus rosa-sinensis Linn. roots,” Evidence-Based Complementary and Alternative Medicine, vol. 5, no. 1, pp. 91–94, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. B. Shivananda Nayak, S. Sivachandra Raju, F. A. Orette, and A. V. Chalapathi Rao, “Effects of Hibiscus rosa sinensis L (Malvaceae) on wound healing activity: a preclinical study in a Sprague Dawley rat,” International Journal of Lower Extremity Wounds, vol. 6, no. 2, pp. 76–81, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. V. S. Kasture, C. T. Chopde, and V. K. Deshmukh, “Anticonvulsive activity of Albizzia lebbeck, Hibiscus rosa sinesis and Butea monosperma in experimental animals,” Journal of Ethnopharmacology, vol. 71, no. 1-2, pp. 65–75, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Yamasaki, H. Uefuji, and Y. Sakihama, “Bleaching of the red anthocyanin induced by superoxide radical,” Archives of Biochemistry and Biophysics, vol. 332, no. 1, pp. 183–186, 1996. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Suchalatha and C. S. Shyamala Devi, “Effect of arogh—a polyherbal formulation on the marker enzymes in isoproterenol induced myocardial injury,” Indian Journal of Clinical Biochemistry, vol. 19, no. 2, pp. 184–189, 2004. View at Google Scholar · View at Scopus
  24. A. Adameová, T. Ravingerová, P. Švec, V. Faberová, and M. Kuželová, “The myocardial infarct size-limiting and antiarrhythmic effects of acyl-CoA: cholesterol acyltransferase inhibitor VULM 1457 protect the hearts of diabetic-hypercholesterolaemic rats against ischaemia/reperfusion injury both in vitro and in vivo,” European Journal of Pharmacology, vol. 576, no. 1–3, pp. 114–121, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. M. J. A. Walker, M. J. Curtis, D. J. Hearse et al., “The Lambeth conventions: guidelines for the study of arrhythmias in ischaemia, infarction, and reperfusion,” Cardiovascular Research, vol. 22, no. 7, pp. 447–455, 1988. View at Google Scholar · View at Scopus
  26. T. Ravingerová, J. Neckář, and F. Kolář, “Ischemic tolerance of rat hearts in acute and chronic phases of experimental diabetes,” Molecular and Cellular Biochemistry, vol. 249, no. 1-2, pp. 167–174, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Matejíková, J. Kucharská, M. Pintérová, D. Pancza, and T. Ravingerová, “Protection against ischemia-induced ventricular arrhythmias and myocardial dysfunction conferred by preconditioning in the rat heart: involvement of mitochondrial KATP channels and reactive oxygen species,” Physiological Research, vol. 58, no. 1, pp. 9–19, 2009. View at Google Scholar · View at Scopus
  28. P. Pasdois, C. L. Quinlan, A. Rissa et al., “Ouabain protects rat hearts against ischemia-reperfusion injury via pathway involving src kinase, mitoKATP, and ROS,” American Journal of Physiology, vol. 292, no. 3, pp. H1470–H1478, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Bae and L. Zhang, “Gender differences in cardioprotection against ischemia/reperfusion injury in adult rat hearts: focus on akt and protein kinase C signaling,” Journal of Pharmacology and Experimental Therapeutics, vol. 315, no. 3, pp. 1125–1135, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Hobbs, P. Foster, C. Prescott, R. Scotland, and A. Ahluwalia, “Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide,” Circulation, vol. 110, no. 10, pp. 1231–1235, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. H. V. Schaff, V. L. Gott, R. A. Goldman, J. W. Frederiksen, and J. T. Flaherty, “Mechanism of elevated left ventricular end-diastolic pressure after ischemic arrest and reperfusion,” The American journal of physiology, vol. 240, no. 2, pp. H300–307, 1981. View at Google Scholar · View at Scopus
  32. M. Barteková, S. Čarnická, D. Pancza, M. Ondrejčáková, A. Breier, and T. Ravingerova, “Acute treatment with polyphenol quercetin improves postischemic recovery of isolated perfused rat hearts after global ischemia,” Canadian Journal of Physiology and Pharmacology, vol. 88, no. 4, pp. 465–471, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. T. Ravingerová, A. Džurba, N Vrbjar, N. Tribulová, A. Ziegelhöeffer, and J. Slezák, “Free oxygen radicals-induced impairment of heart function: the role of Na, K-ATPase,” Pharmacol (Life Sci Adv), vol. 13, pp. 133–140, 1994. View at Google Scholar
  34. T. Ravingerová, J. Slezák, N. Tribulová, A. Džurba, B. Uhrík, and A. Ziegelhöffer, “Free oxygen radicals contribute to high incidence of reperfusion-induced arrhythmias in isolated rat heart,” Life Sciences, vol. 65, no. 18-19, pp. 1927–1930, 1999. View at Publisher · View at Google Scholar · View at Scopus
  35. P. S. Ray, G. Maulik, G. A. Cordis, A. A. E. Bertelli, A. Bertelli, and D. K. Das, “The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury,” Free Radical Biology and Medicine, vol. 27, no. 1-2, pp. 160–169, 1999. View at Publisher · View at Google Scholar · View at Scopus
  36. P. Kaplan, E. Babusikova, J. Lehotsky, and D. Dobrota, “Free radical-induced protein modification and inhibition of Ca2+-ATPase of cardiac sarcoplasmic reticulum,” Molecular and Cellular Biochemistry, vol. 248, no. 1-2, pp. 41–47, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. J. W. Hoffman Jr., T. B. Gilbert, R. S. Poston, and E. P. Silldorff, “Myocardial reperfusion injury: etiology, mechanisms, and therapies,” Journal of Extra-Corporeal Technology, vol. 36, no. 4, pp. 391–411, 2004. View at Google Scholar · View at Scopus
  38. O. Szárszoi, G. Asemu, J. Vaněček, B. Ošt'ádal, and F. Kolář, “Effects of melatonin on ischemia and reperfusion injury of the rat heart,” Cardiovascular Drugs and Therapy, vol. 15, no. 3, pp. 251–257, 2001. View at Publisher · View at Google Scholar · View at Scopus
  39. R. Važan, D. Pancza, I. Béder, and J. Styk, “Ischemia-reperfusion injury—antiarrhythmic effect of melatonin associated with reduced recovering of contractility,” General Physiology and Biophysics, vol. 24, no. 3, pp. 355–359, 2005. View at Google Scholar · View at Scopus
  40. R. Važan, J. Styk, I. Béder, and D. Pancza, “Effect of melatonin on the isolated heart in the standard perfusion conditions and in the conditions of calcium paradox,” General Physiology and Biophysics, vol. 22, no. 1, pp. 41–50, 2003. View at Google Scholar · View at Scopus
  41. J. Matejíková, J. Kucharská, D. Pancza, and T. Ravingerová, “The effect of antioxidant treatment and NOS inhibition on the incidence of ischaemia-induced arrhythmias in the diabetic rat heart,” Physiological Research, vol. 57, no. 2, pp. S55–S60, 2008. View at Google Scholar · View at Scopus
  42. E. Sahna, H. Parlakpinar, Y. Turkoz, and A. Acet, “Protective effects of melatonin on myocardial ischemia-reperfusion induced infarct size and oxidative changes,” Physiological Research, vol. 54, no. 5, pp. 491–495, 2005. View at Google Scholar · View at Scopus
  43. G. M. M. Rao, Ch. Venkateswararao, A. K. S. Rawat, P. Pushpangadan, and A. Shirwaikar, “Antioxidant and antihepatotoxic activities of Hemidesmus indicus R. Br,” Acta Pharmaceutica Turcica, vol. 47, no. 2, pp. 107–113, 2005. View at Google Scholar · View at Scopus
  44. C.-Y. Hong, C.-P. Wang, S.-S. Huang, and F.-L. Hsu, “The inhibitory effect of tannins on lipid peroxidation of rat heart mitochondria,” Journal of Pharmacy and Pharmacology, vol. 47, no. 2, pp. 138–142, 1995. View at Google Scholar · View at Scopus
  45. H. Matsuura, “Saponins in garlic as modifiers of the risk of cardiovascular disease,” Journal of Nutrition, vol. 131, no. 3, pp. 1000S–1005S, 2001. View at Google Scholar · View at Scopus
  46. C. A. Schmitt and V. M. Dirsch, “Modulation of endothelial nitric oxide by plant-derived products,” Nitric Oxide, vol. 21, no. 2, pp. 77–91, 2009. View at Publisher · View at Google Scholar · View at Scopus
  47. M. Akhlaghi and B. Bandy, “Mechanisms of flavonoid protection against myocardial ischemia-reperfusion injury,” Journal of Molecular and Cellular Cardiology, vol. 46, no. 3, pp. 309–317, 2009. View at Publisher · View at Google Scholar · View at Scopus
  48. K. K. Gauthaman, M. T. S. Saleem, P. T. Thanislas et al., “Cardioprotective effect of the Hibiscus rosa sinensis flowers in an oxidative stress model of myocardial ischemic reperfusion injury in rat,” BMC Complementary and Alternative Medicine, vol. 6, article no. 32, 2006. View at Publisher · View at Google Scholar · View at Scopus
  49. J. Duarte, R. Pérez-Palencia, F. Vargas et al., “Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats,” British Journal of Pharmacology, vol. 133, no. 1, pp. 117–124, 2001. View at Google Scholar · View at Scopus
  50. M. Ibarra, L. Moreno, R. Vera et al., “Effects of the flavonoid quercetin and its methylated metabolite isorhamnetin in isolated arteries from spontaneously hypertensive rats,” Planta Medica, vol. 69, no. 11, pp. 995–1000, 2003. View at Publisher · View at Google Scholar · View at Scopus
  51. A. Machha, F. I. Achike, A. M. Mustafa, and M. R. Mustafa, “Quercetin, a flavonoid antioxidant, modulates endothelium-derived nitric oxide bioavailability in diabetic rat aortas,” Nitric Oxide, vol. 16, no. 4, pp. 442–447, 2007. View at Publisher · View at Google Scholar · View at Scopus
  52. D.-S. Kim, K.-C. Ha, D.-Y. Kwon et al., “Kaempferol protects ischemia/reperfusion-induced cardiac damage through the regulation of endoplasmic reticulum stress,” Immunopharmacology and Immunotoxicology, vol. 30, no. 2, pp. 257–270, 2008. View at Publisher · View at Google Scholar · View at Scopus