Epigenetics in Traditional Chinese Pharmacy: A Bioinformatic Study at Pharmacopoeia Scale
Figure 4
Top 15 flavor distribution of mechanism-specific epigenetic TCMMs. In total, 2540 TCMMs have flavor annotation. Among them 822 are epigenetic. DNMT-interacting TCMMs are overrepresented in sweet (P = 7.1 × 10−5); HDAC-interacting medicinals in sweet, sweet-sour and sour-sweet (P = 2.4 × 10−5, 7.5 × 10−5 and 1.7 × 10−3, resp.); HAT-interacting medicinals in bitter-sweet-astringent (P = 8.4 × 10−3); MBD-interacting medicinals in salty (P = 7.4 × 10−5); PcG-interacting medicinals in sweet-plain and bitter-astringent (P = 3.8 × 10−3 and 6.7 × 10−3); and DICER-interacting medicinals in sweet (P = 1.2 × 10−3). The above overrepresentations are for P < .01.
