Phytomedicinal Role of Pithecellobium dulce against CCl₄-mediated Hepatic Oxidative Impairments and Necrotic Cell Death

Table 6

Status of the thiol-based antioxidant in the liver tissue of the CCl₄- and AEPD-treated animals.

Animal groups	GSH	GSSG	Total thiols
Vehicle	29.53 ± 1.52(a)	3.45 ± 0.19(a)	315.31 ± 15.76(a)
AEPD	25.74 ± 1.29(a)	3.51 ± 0.18(a)	305.25 ± 15.31(a)
CCl4	8.34 ± 0.45(b)	5.75 ± 0.28(b)	155.89 ± 7.85(b)
AEPD + CCl4	21.45 ± 1.09(a),(c)	3.85 ± 0.19(a)	255.34 ± 12.74(a)
CCl4 + AEPD	18.74 ± 0.95(c)	4.01 ± 0.21(a)	275.55 ± 13.79(a)
VitC + CCl4	23.45 ± 1.21(a)	3.69 ± 0.18(a)	297.31 ± 14.92(a)
Recovery	9.15 ± 0.49(b)	5.55 ± 0.27(b)	168.52 ± 8.45(b)

GSH—nmol mg⁻¹ protein; GSSG—nmol mg⁻¹ protein and total thiols—nmol mg⁻¹ protein. Data are mean ± SD, for six animals per group and were analyzed by one-way ANOVA, with Student-Newman-Keuls post hoc tests. Differences were attributed at P < .05, and homogeneous subgroups share common superscripted letters.