The Herb Medicine Formula “Chong Lou Fu Fang” Increases the Cytotoxicity of Chemotherapeutic Agents and Down-Regulates the Expression of Chemotherapeutic Agent Resistance-Related Genes in Human Gastric Cancer Cells In Vitro
Figure 5
Effect of CLFF on the expression of
chemotherapeutic agent resistance-related genes in SGC-7901 cells.
The level of ERCC1, TS, β-tubulin III and tau mRNA expression, followed
treatment with CLFF and every chemotherapeutic agent singly at their
respective IC40 or in combination for 24 h, was determined in SGC-7901
cells by real-time RT-PCR. a1: cells were treated with 5-fluorouracil
alone. a2: cells were treated with oxaliplatin alone. a3: cells were
treated with docetaxel alone. b1: cells were treated with CLFF combination
with 5-fluorouracil. b2: cells were treated with CLFF combination with oxaliplatin.
b3: cells were treated with CLFF combination with docetaxel. Data point, means of at
least three independent experiment; bars, SD. versus
control cells.
