Evidence-Based Complementary and Alternative Medicine / 2011 / Article / Fig 2

Original Article

Agaricus blazei Extract Induces Apoptosis through ROS-Dependent JNK Activation Involving the Mitochondrial Pathway and Suppression of Constitutive NF-κB in THP-1 Cells

Figure 2

Effect of ABE on mitochondrial function and ROS generation. THP-1 cells were seeded at 2 × 105 cells ml−1 and were then treated with 4 mg ml−1 of ABE for the indicated time. (a) The mitochondrial membrane potential was determined by flow cytometer using DiOC6 labeling of mitochondria. (b) The redox status was monitored by the oxidation-sensitive fluorescent dyes for H2O2 (DCFDA) and O2 (HE). The results shown are from one representative experiment of three experiments that showed exhibited similar patterns.

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