<i>Agaricus blazei</i> Extract Induces Apoptosis through ROS-Dependent JNK Activation Involving the Mitochondrial Pathway and Suppression of Constitutive NF-<i>κ</i>B in THP-1 Cells

<table>Proposed mechanisms for the apoptotic 
effects of ABE in THP-1 cells. The apoptotic mechanism was mediated by 
the generation of ROS, phosphorylation of JNK, release of cytochrome 
<i>c</i> into cytoplasm, and activation of caspases. Additionally, 
expression of IAPs, which have inhibitory effect of caspases, was abolished by 
inhibition of NF-<i>κ</i>B.</table>

Evidence-Based Complementary and Alternative Medicine

fig7

Figure 7

Figure 7: <i>Agaricus blazei</i> Extract Induces Apoptosis through ROS-Dependent JNK Activation Involving the Mitochondrial Pathway and Suppression of Constitutive NF-<i>κ</i>B in THP-1 Cells 

Figure 7 | Agaricus blazei Extract Induces Apoptosis through ROS-Dependent JNK Activation Involving the Mitochondrial Pathway and Suppression of Constitutive NF-κB in THP-1 Cells 