Research Article

Effect of Supplementation of Tanshinone IIA and Sodium Tanshinone IIA Sulfonate on the Anticancer Effect of Epirubicin: An In Vitro Study

Table 1

Interaction between STS (or Tan IIA) and epirubicin on the growth of BT-20 breast cancer cells.

Epirubicin (μg/mL)STS (μg/mL)Tan IIA (μg/mL)FaCIEffect

0.03125250.0482.014Antagonistic
0.0625250.03133.931Antagonistic
0.125250.06863.314Antagonistic
0.25250.08694.713Antagonistic
0.5250.14475.626Antagonistic
1250.23236.95Antagonistic
2250.79022.038Antagonistic

0.03125500.04923.166Antagonistic
0.0625500.03515.15Antagonistic
0.125500.07763.825Antagonistic
0.25500.06836.652Antagonistic
0.5500.24.557Antagonistic
1500.4233.733Antagonistic
2500.89461.131Additive/antagonistic

0.03125250.61091.066Additive/antagonistic
0.0625250.50971.302Additive/antagonistic
0.125250.63541.197Additive/antagonistic
0.25250.83710.902Synergistic
0.5250.82571.141Additive/antagonistic
1250.83411.511Antagonistic
2250.89261.708Antagonistic

0.03125500.94121.013Additive/antagonistic
0.0625500.94221.018Additive/antagonistic
0.125500.93921.057Additive/antagonistic
0.25500.93821.106Additive/antagonistic
0.5500.93661.205Additive/antagonistic
1500.93721.377Antagonistic
2500.93741.728Antagonistic

Fa: fraction affected; CI: combination index.
A value of CI <1 represents a case where synergism of epirubicin and STS (or Tan IIA) was present. CI values of 1 and >1 represent additive and antagonistic effects, respectively.