Evidence-Based Complementary and Alternative Medicine / 2011 / Article / Fig 1

Research Article

Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors

Figure 1

Effects of different fresh Valerian extracts (1 mg/mL) on [3H]Glutamate binding to rat synaptic membranes in the presence of 1 mM glutamate receptor (GluR) ligands. (a) The aqueous extract decreases the effects of the NMDA (MK-801), AMPA, and Kainate (KA), but it did not alter the effects of quisqualic acid (QA), a group I metabotropic glutamate receptor (mGluR) ligand. (b) The hydroalcoholic extract also decreases the effects of NMDA, AMPA, and KA. In contrast, Valerian reverses the inhibitory effects of QA. +agonist versus agonist + Valerian, ; ++ ; +++ .

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