Antinociceptive Activities and the Mechanisms of Anti-Inflammation of Asiatic Acid in Mice
Figure 8
Histological appearance of the mouse hind footpad after a subcutaneous injection with Carr stained with H & E stain at the fifth hour to reveal hemorrhage, edema, and inflammatory cell infiltration in (a) control mice, (b) Carr-treated mice demonstrating hemorrhage with moderately extravascular red blood cells and a large amount of inflammatory leukocytemainly neutrophils infiltration in the subdermis interstitial tissue of mice, and (c) mice given Indo (10 mg/kg) before Carr. AA significantly shows (d) morphological alterations (100x) and (e) the numbers of neutrophils in each scope (400x) compared to subcutaneous injection of Carr only. ### as compared with the control group. *** compared with Carr group. Scale bar = 100 μm.