San-Huang-Xie-Xin-Tang Prevents Rat Hearts from Ischemia/Reperfusion-Induced Apoptosis through eNOS and MAPK Pathways

<table>SHXT up-regulated eNOS protein expression and then promoted plasma NO production after I/R. (a) The expression level of eNOS protein in infarcted myocardial tissues was measured by immunoblot assay. The relative ratio of protein/<i>β</i>-actin protein was quantified by densitometric analyses. (b) NO production was detected spectrophotometrically by measuring its metabolite, nitrite. Each value represents the mean ± SEM of six rats. <svg height="13.95" id="M21" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.162498 13.95" width="58.162498" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus sham group; <svg height="14.3125" id="M22" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.162498 14.3125" width="58.162498" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus vehicle-treated rats. ANOVA followed by Dunnett’s test.</table>

Evidence-Based Complementary and Alternative Medicine

fig3

Figure 3

Figure 3: San-Huang-Xie-Xin-Tang Prevents Rat Hearts from Ischemia/Reperfusion-Induced Apoptosis through eNOS and MAPK Pathways 