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Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 915240, 8 pages
Original Article

Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction

1Interdisciplinary School of Health Sciences, University of Pune, Pune 411007, India
2University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
3National Center for Cell Sciences, Pune, India
4Applied Biotech, Vile Parle, Mumbai, India
5National Toxicology Center, Pune, India
6ICMR—Advanced Centre of Reverse Pharmacology, MRC-KHS, Vile Parle, Mumbai, India
7Manipal Education, Bangalore 560008, India

Received 8 April 2009; Accepted 12 December 2009

Copyright © 2011 Amrutesh S. Puranik et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-based supercritical extract of Cassia auriculata for 12 weeks. Our studies indicate that both these extracts are pharmacologically safe and did not show any significant adverse reactions at the tested doses. The traditional hydro-alcoholic extract did not show any significant effect on pharmacokinetics; however, the technology-based supercritical extract caused a significant reduction in absorption of metformin. Our results indicate the need to include pharmacokinetic herb-drug interaction studies as evidence for safety especially for technology-based extracts.