Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 965016, 14 pages
http://dx.doi.org/10.1155/2011/965016
Research Article

Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways

1Department of Pharmacology, Key Laboratory of New Drug Screening of Liaoning Province, Shenyang Pharmaceutical University, Shenyang 110016, China
2Department of Hematology, Shenyang Military General Hospital, Shenyang 110016, China

Received 22 January 2011; Accepted 21 March 2011

Copyright © 2011 Hong Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Y. Su, “Treatment of lung cancer with brain metastasis using an intravenous drip of a 10% emulsion of Brucea javanica seminal oil,” Chinese Journal of Integrative Medicine, vol. 5, no. 2, pp. 86–88, 1985. View at Google Scholar · View at Scopus
  2. L. Ma and Y. N. Zhang, “Effects of seminal oil emulsion of Brucea javanica on apoptosis and apoptosis-related genes in human hepatocellular carcinoma cells,” World Chinese Journal of Digestology, vol. 12, no. 3, pp. 559–562, 2004. View at Google Scholar · View at Scopus
  3. D. L. He, X. Y. Nan, and W. S. Liu, “The antitumor effect of 10% Brucea Javanica oil emulsion on prostate cancer cells,” Journal of Clinical Urology, vol. 9, pp. 60–62, 1994. View at Google Scholar
  4. X. W. Li, H. Wang, W. J. Qin, X. Li, T. Liu, and C. M. Fan, “Necrosis and apoptosis induced by Brucea Javanica oil emulsion in bladder cancer cell,” Chinese Journal Rehabilitation Theory and Practice, vol. 10, no. 3, pp. 163–165, 2004. View at Google Scholar
  5. Y. Li, Y. Li, L. Y. Zhang, and G. L. Xu, “Experimental study of Brucea Javanica oil emulsion induceds K562 cell apoptosis and its mechanism,” Journal of International Oncology, vol. 33, no. 8, pp. 637–639, 2006. View at Google Scholar
  6. X. Jiang, Y. Y. Zeng, J. F. Di et al., “Preliminary studies on the effects of Brucea Javanica emulsion on HPV positive tumor cells form laryngeal papilloma in child,” Journal of Jinan University (Medicine Edition), vol. 25, no. 4, pp. 408–412, 2004. View at Google Scholar
  7. X. J. Yin, H. Z. Luan, C. L. An, X. L. Wang, Y. Y. Bing, and X. N. Wang, “Inhibitory effect of Brucea javanica oil emulsion against cervical cancer cell line Hela and its mechanism,” Chinese Journal of Cancer Biotherapy, vol. 15, no. 4, pp. 393–395, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Xia, D. Chen, R. Han, Q. Fang, S. Waxman, and Y. Jing, “Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells,” Molecular Cancer Therapeutics, vol. 4, no. 3, pp. 381–388, 2005. View at Google Scholar · View at Scopus
  9. M. S. Tallman, D. G. Gilliland, and J. M. Rowe, “Drug therapy for acute myeloid leukemia,” Blood, vol. 106, no. 4, pp. 1154–1163, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. W. Wang, E. R. Rayburn, M. Hao et al., “Experimental therapy of prostate cancer with novel natural product anti-cancer ginsenosides,” Prostate, vol. 68, no. 8, pp. 809–819, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. S. O'Brien, M. Talpaz, J. Cortes et al., “Simultaneous homoharringtonine and interferon-α in the treatment of patients with chronic-phase chronic myelogenous leukemia,” Cancer, vol. 94, no. 7, pp. 2024–2032, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. D. C. Zhou, R. Zittoun, and J. P. Marie, “Homoharringtonine: an effective new natural product in cancer chemotherapy,” Bulletin du Cancer, vol. 82, no. 12, pp. 987–995, 1995. View at Google Scholar · View at Scopus
  13. M. A. Barry, J. E. Reynolds, and A. Eastman, “Etoposide-induced apoptosis in human HL-60 cells is associated with intracellular acidification,” Cancer Research, vol. 53, no. 10, pp. 2349–2357, 1993. View at Google Scholar · View at Scopus
  14. T. Efferth, P. C. H. Li, V. S. B. Konkimalla, and B. Kaina, “From traditional Chinese medicine to rational cancer therapy,” Trends in Molecular Medicine, vol. 13, no. 8, pp. 353–361, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. H. M. Wang, G. Q. Liao, P. H. Liu, Y. M. Qu, G. Q. Xie, and S. X. Liu, “Clinical study on the treatment of malignant pleural effusions by intracavitary application with Cisplatin combined with Brucea javanica oil emulsion,” Modern Chinese Meidicine, vol. 9, no. 2, pp. 23–24, 2007. View at Google Scholar
  16. M. Du and M. Shi, “Clinical effect of Brucea javanical oil emulsion combined with chemotherapy on the treatment of nonsmall- cell lung cancer,” Journal of Basic and Clinical Oncology, vol. 19, no. 2, pp. 151–152, 2006. View at Google Scholar
  17. C. L. Mackall, T. A. Fleisher, M. R. Brown et al., “Lymphocyte depletion during treatment with intensive chemotherapy for cancer,” Blood, vol. 84, no. 7, pp. 2221–2228, 1994. View at Google Scholar · View at Scopus
  18. S. Rubio, J. Quintana, M. López, J. L. Eiroa, J. Triana, and F. Estévez, “Phenylbenzopyrones structure-activity studies identify betuletol derivatives as potential antitumoral agents,” European Journal of Pharmacology, vol. 548, no. 1–3, pp. 9–20, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. Z. Yu, R. Wang, L. Xu, J. Dong, and Y. Jing, “N-(β-Elemene-13-yl)tryptophan methyl ester induces apoptosis in human leukemia cells and synergizes with arsenic trioxide through a hydrogen peroxide dependent pathway,” Cancer Letters, vol. 269, no. 1, pp. 165–173, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. H. Han, S. Z. Kim, S. H. Kim, and W. H. Park, “Arsenic trioxide inhibits the growth of Calu-6 cells via inducing a G2 arrest of the cell cycle and apoptosis accompanied with the depletion of GSH,” Cancer Letters, vol. 270, no. 1, pp. 40–55, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. Z. Cai, H. Y. Bao, and M. F. Lin, “Correlation between survivin mRNA expression and homoharringtonine induced apoptosis of malignant hematopoietic cells,” Chinese Medical Journal, vol. 118, no. 7, pp. 548–554, 2005. View at Google Scholar · View at Scopus
  22. L. Hou, C. Ju, J. Zhang, J. Song, Y. Ge, and W. Yue, “Antitumor effects of Isatin on human neuroblastoma cell line (SH-SY5Y) and the related mechanism,” European Journal of Pharmacology, vol. 589, no. 1–3, pp. 27–31, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. Q. Tong, F. Zeng, C. Lin, J. Zhao, and G. Lu, “Growth inhibiting effects of antisense eukaryotic expression vector of proliferating cell nuclear antigen gene on human bladder cancer cells,” Chinese Medical Journal, vol. 116, no. 8, pp. 1203–1206, 2003. View at Google Scholar · View at Scopus
  24. Z. L. Jin, Y. K. Zhang, H. Y. Sun et al., “Osteogenic-related gene expression profiles of human dental follicle cells induced by dexamethasone,” Acta Pharmacologica Sinica, vol. 29, no. 9, pp. 1013–1020, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. Jing, J. Dai, R. M. E. Chalmers-Redman, W. G. Tatton, and S. Waxman, “Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway,” Blood, vol. 94, no. 6, pp. 2102–2111, 1999. View at Google Scholar · View at Scopus
  26. M. J. Liu, Z. Wang, H. X. Li, R. C. Wu, Y. Z. Liu, and Q. Y. Wu, “Mitochondrial dysfunction as an early event in the process of apoptosis induced by woodfordin I in human leukemia K562 cells,” Toxicology and Applied Pharmacology, vol. 194, no. 2, pp. 141–155, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. D. W. Nicholson and N. A. Thornberry, “Caspases: killer proteases,” Trends in Biochemical Sciences, vol. 22, no. 8, pp. 299–306, 1997. View at Publisher · View at Google Scholar · View at Scopus
  28. T. W. Day, S. Huang, and A. R. Safa, “c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells,” Biochemical Pharmacology, vol. 76, no. 12, pp. 1694–1704, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. C. Borner, “The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions,” Molecular Immunology, vol. 39, no. 11, pp. 615–647, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Mohapatra, B. Chu, X. Zhao, and W. J. Pledger, “Accumulation of p53 and reductions in XIAP abundance promote the apoptosis of prostate cancer cells,” Cancer Research, vol. 65, no. 17, pp. 7717–7723, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. K. Atjanasuppata, W. Wongkhama, P. Meepowpanb et al., “In vitro screening for anthelmintic and antitumour activity of ethnomedicinal plants from Thailand,” Journal of Ethnopharmacology, vol. 123, pp. 475–482, 2009. View at Google Scholar
  32. M. Smith, M. Barnett, R. Bassan, G. Gatta, C. Tondini, and W. Kern, “Adult acute myeloid leukaemia,” Critical Reviews in Oncology/Hematology, vol. 50, no. 3, pp. 197–222, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. D. L. Vaux and J. Silke, “Mammalian mitochondrial IAP binding proteins,” Biochemical and Biophysical Research Communications, vol. 304, no. 3, pp. 499–504, 2003. View at Publisher · View at Google Scholar · View at Scopus
  34. R. Tang, A. M. Faussat, P. Majdak et al., “Semisynthetic homoharringtonine induces apoptosis via inhibition of protein synthesis and triggers rapid myeloid cell leukemia-1 down-regulation in myeloid leukemia cells,” Molecular Cancer Therapeutics, vol. 5, no. 3, pp. 723–731, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. M. F. Cury-Boaventura, C. Pompéia, and R. Curi, “Comparative toxicity of oleic acid and linoleic acid on Jurkat cells,” Clinical Nutrition, vol. 23, no. 4, pp. 721–732, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Miglietta, F. Bozzo, C. Bocca et al., “Conjugated linoleic acid induces apoptosis in MDA-MB-231 breast cancer cells through ERK/MAPK signalling and mitochondrial pathway,” Cancer Letters, vol. 234, no. 2, pp. 149–157, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Zhang, F. Yang, F. Yang, C. Y. Zheng, and YI. Liang, “Cytotoxic aggregates of α-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells,” Chemico-Biological Interactions, vol. 180, no. 2, pp. 131–142, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. M. F. Cury-Boaventura, C. C. Kanunfre, R. Gorjão, T. M. de Lima, and R. Curi, “Mechanisms involved in Jurkat cell death induced by oleic and linoleic acids,” Clinical Nutrition, vol. 25, no. 6, pp. 1004–1014, 2006. View at Publisher · View at Google Scholar · View at Scopus