HMC05, Herbal Formula, Inhibits TNF-α-Induced Inflammatory Response in Human Umbilical Vein Endothelial Cells

Figure 8

Schematic diagram showing signaling pathway HMC05 action against TNF-α-induced vascular inflammation. HMC05 may protect vascular inflammation through suppression of ROS production and the expression of NF-κB-related adhesion molecules in endothelial cells, which in turn, prevents monocyte adhesion to endothelial cells. TNFR: tumor necrosis factor-α receptor. The solid arrow and broken arrow represent activation, and migration, respectively.