Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans

Table 1

MIC of pseudolaric acid B against Candida species.

Species	Total Number	PSE MIC/MFC	FLZ MIC
C. tropicalis	4	32.00±20.13 *	1.19±3.63
C. krusei	4	53.82±16.00	53.82.00±16.00
C. dubliniensis	4	53.82±16.00	1.68±3.47
C. glabrata	4	32.00±20.13	11.37±12.38
C. guilliermondii	4	32.00±20.13	3.36±1.00
C. albicans	15	42.22±26.68	11.06±37.76
C. k. ATCC 6258	1	64	32∼64
C. a ATCC 90028	1	32	0.5∼1

MIC: minimum inhibitory concentration; MFC: minimum fungicidal concentration; PSE: pseudolaric acid B; FLZ: fluconazole. *Data were demonstrated as geometric mean titer ± SD.