Research Article

Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans

Table 2

MIC of pseudolaric acid B against C. albicans strains isolated from different sources.

SpeciesIsolate no.PSE (μg/mL) MIC/MFCPSE (mmol/L)FLZ (μg/mL)
MIC50MFC

C. albicansSS320.07464128
C. albicansSS320.074128256
C. albicansSS320.07464128
C. albicansSS320.07464128
C. albicansSS320.07432128
C. albicansHIV(−)640.148264
C. albicansHIV(−)320.0740.532
C. albicansHIV(−)640.148264
C. albicansHIV(−)640.1488128
C. albicansHIV(−)320.074464
C. albicansHIV(+)1280.29616128
C. albicansHIV(+)320.07464128
C. albicansHIV(+)320.0744128
C. albicansHIV(+)320.0748128
C. albicansHIV(+)640.148264

MIC: minimum inhibitory concentration; MFC: minimum fungicidal concentration; PSE: pseudolaric acid B; FLZ: fluconazole; SS: Sjögren’s syndrome.