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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 125761, 9 pages
http://dx.doi.org/10.1155/2012/125761
Review Article

Eurycoma longifolia: Medicinal Plant in the Prevention and Treatment of Male Osteoporosis due to Androgen Deficiency

Department of Pharmacology, Faculty of Medicine, The National University of Malaysia, Kuala Lumpur Campus, 50300 Kuala Lumpur, Malaysia

Received 26 April 2012; Accepted 6 June 2012

Academic Editor: Ima Nirwana Soelaiman

Copyright © 2012 Nadia Mohd Effendy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Osteoporosis in elderly men is now becoming an alarming health issue due to its relation with a higher mortality rate compared to osteoporosis in women. Androgen deficiency (hypogonadism) is one of the major factors of male osteoporosis and it can be treated with testosterone replacement therapy (TRT). However, one medicinal plant, Eurycoma longifolia Jack (EL), can be used as an alternative treatment to prevent and treat male osteoporosis without causing the side effects associated with TRT. EL exerts proandrogenic effects that enhance testosterone level, as well as stimulate osteoblast proliferation and osteoclast apoptosis. This will maintain bone remodelling activity and reduce bone loss. Phytochemical components of EL may also prevent osteoporosis via its antioxidative property. Hence, EL has the potential as a complementary treatment for male osteoporosis.