Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin

Table 4

Pharmacokinetic parameters of nifedipine in healthy subjects after a single dose of 5 mg nifedipine capsule with or without 600 mg LipoCol Forte capsule in the fasted state. The data were given as mean ± SD for 14 subjects.

	Nifedipine alone	Nifedipine with LipoCol Forte
	Mean ± SD	Mean ± SD
AUC0-16 (ng ×h/mL)	131.7 ± 37.0	135.3 ± 27.8
AUC0-inf (ng × h/mL)	136.5 ± 38.2	140.8 ± 29.4
𝐶max (ng/mL)	81.46 ± 25.62	71.78 ± 23.56
𝑇max (h)	0.46 ± 0.15	0.55 ± 0.43
MRT (h)	3.68 ± 0.59	3.89 ± 0.97
𝑇1/2(h)	3.62 ± 0.90	3.58 ± 1.39
CL/F (L/h)	40.2 ± 14.9	37.3 ± 9.9
𝑉𝑑/F (L)	201.4 ± 56.1	186.8 ± 69.9