Research Article

Efficacy of Boesenbergia rotunda Treatment against Thioacetamide-Induced Liver Cirrhosis in a Rat Model

Table 3

Liver index measurements from the rats at the end of the 8-week study.

TreatmentBody weight (gm)Liver weight (gm)Liver index (LW/BW %)

Group 1 (normal rats) 3 4 7 ± 5 . 0 4 9 . 7 0 ± 0 . 1 6 2 . 7 9 ± 0 . 2 1
Group 2 (rats with cirrhosis) 1 8 3 ± 2 . 3 2 9 . 4 4 ± 0 . 6 0 5 . 1 8 ± 0 . 0 6 **
Group 3 (silymarin-treated rats) 3 4 7 ± 3 . 5 8 1 0 . 2 8 ± 0 . 6 6 2 . 9 7 ± 0 . 3 5 *
Group 4 (treatment with the BR extract at 250 mg/kg dose) 2 5 5 ± 2 . 9 1 1 0 . 0 3 ± 0 . 4 6 3 . 9 3 ± 0 . 4 4 *
Group 5 (treatment with the BR extract at 500 mg/kg dose) 3 7 6 ± 5 . 6 7 9 . 7 1 ± 0 . 7 1 2 . 5 9 ± 0 . 3 6 *

Data were expressed as Mean ± SEM. Means between the silymarin-treated Group 3, low-dose BR-treated Group 4, and high-dose BR-treated Group 5 had significant differences when compared with the cirrhosis control Group 2 with * 𝑃 < 0 . 0 0 1 and compared with the normal control Group 1 with ** 𝑃 < 0 . 0 0 1 .