Beneficial Effect of Traditional Chinese Medicinal Formula Danggui-Shaoyao-San on Advanced Glycation End-Product-Mediated Renal Injury in Streptozotocin-Diabetic Rats

Table 1

Changes of the body weights, plasma parameters, and SBP in STZ-diabetic rats receiving DSS treatment.

	Period (week)	Body weight (g)	Plasma glucose (mg dL^−1)	Plasma cholesterol (mg dL^−1)	Plasma triglyceride (mg dL^−1)	SBP (mm Hg)
Nondiabetic rats
Vehicle	0	193.3 ± 11.2	92.8 ± 2.4^d	68.5 ± 4.1^c	94.2 ± 7.6^d	87.3 ± 3.1^c
	4th	223.8 ± 10.4^c	93.6 ± 3.4^d	69.4 ± 3.8^c	100.4 ± 6.8^d	89.4 ± 2.9^c
	8th	247.6 ± 13.1^c	95.4 ± 2.7^d	70.2 ± 3.4^c	98.4 ± 8.2^d	90.3 ± 3.7^c
	12th	262.6 ± 12.3^c	96.8 ± 3.1^d	71.3 ± 3.6^c	98.6 ± 6.4^d	92.6 ± 3.4^c
STZ-diabetic rats
Vehicle	0	183.7 ± 10.5	408.6 ± 3.7^b	110.9 ± 4.2^a	338.4 ± 8.3^b	115.5 ± 4.4^a
	4th	176.2 ± 9.5^a	412.5 ± 3.8^b	114.6 ± 3.9^a	345.6 ± 9.2^b	124.6 ± 3.7^a
	8th	168.3 ± 8.9^a	418.7 ± 4.1^b	118.1 ± 4.1^a	349.2 ±12.4^b	129.8 ± 3.9^a
	12th	160.5 ± 11.4^a	423.2 ± 4.4^b	118.4 ± 4.7^a	353.5 ± 10.1^b	134.5 ± 3.6^a
DSS (2.8 g kg^−1 per day)	0	184.1 ± 9.7	409.6 ± 4.1^b	112.3 ± 4.8^a	339.2 ± 8.1^b	115.1 ± 4.3^a
	4th	180.2 ± 11.3^a	405.7 ± 5.6^b	112.1 ± 3.7^a	344.2 ± 11.3^b	122.4 ± 3.5^a
	8th	177.4 ± 9.5^a	390.2 ± 3.8^b, c	116.8 ± 3.2^a	348.5 ±10.1^b	120.6 ± 4.1^a
	12th	170.1 ± 10.9^a	381.5 ± 4.2^b, c	115.3 ± 3.9^a	340.3 ± 8.1^b	130.1 ± 4.5^a

Values (mean ± SD) were obtained for each group of 8 animals. ^a𝑃<0.05 and ^b𝑃<0.01 compared to the values of vehicle-treated nondiabetic rats at the corresponding time, respectively. ^c𝑃<0.05 and ^d𝑃<0.01 compared to the values of vehicle-treated STZ-diabetic rats at the corresponding time, respectively.