Beneficial Effect of Traditional Chinese Medicinal Formula Danggui-Shaoyao-San on Advanced Glycation End-Product-Mediated Renal Injury in Streptozotocin-Diabetic Rats
Table 1
Changes of the body weights, plasma parameters, and SBP in STZ-diabetic rats receiving DSS treatment.
Period (week)
Body weight (g)
Plasma glucose (mg dL−1)
Plasma cholesterol (mg dL−1)
Plasma triglyceride (mg dL−1)
SBP (mm Hg)
Nondiabetic rats
Vehicle
0
193.3 ± 11.2
92.8 ± 2.4d
68.5 ± 4.1c
94.2 ± 7.6d
87.3 ± 3.1c
4th
223.8 ± 10.4c
93.6 ± 3.4d
69.4 ± 3.8c
100.4 ± 6.8d
89.4 ± 2.9c
8th
247.6 ± 13.1c
95.4 ± 2.7d
70.2 ± 3.4c
98.4 ± 8.2d
90.3 ± 3.7c
12th
262.6 ± 12.3c
96.8 ± 3.1d
71.3 ± 3.6c
98.6 ± 6.4d
92.6 ± 3.4c
STZ-diabetic rats
Vehicle
0
183.7 ± 10.5
408.6 ± 3.7b
110.9 ± 4.2a
338.4 ± 8.3b
115.5 ± 4.4a
4th
176.2 ± 9.5a
412.5 ± 3.8b
114.6 ± 3.9a
345.6 ± 9.2b
124.6 ± 3.7a
8th
168.3 ± 8.9a
418.7 ± 4.1b
118.1 ± 4.1a
349.2 ±12.4b
129.8 ± 3.9a
12th
160.5 ± 11.4a
423.2 ± 4.4b
118.4 ± 4.7a
353.5 ± 10.1b
134.5 ± 3.6a
DSS (2.8 g kg−1 per day)
0
184.1 ± 9.7
409.6 ± 4.1b
112.3 ± 4.8a
339.2 ± 8.1b
115.1 ± 4.3a
4th
180.2 ± 11.3a
405.7 ± 5.6b
112.1 ± 3.7a
344.2 ± 11.3b
122.4 ± 3.5a
8th
177.4 ± 9.5a
390.2 ± 3.8b, c
116.8 ± 3.2a
348.5 ±10.1b
120.6 ± 4.1a
12th
170.1 ± 10.9a
381.5 ± 4.2b, c
115.3 ± 3.9a
340.3 ± 8.1b
130.1 ± 4.5a
Values (mean ± SD) were obtained for each group of 8 animals. a and b compared to the values of vehicle-treated nondiabetic rats at the corresponding time, respectively. c and d compared to the values of vehicle-treated STZ-diabetic rats at the corresponding time, respectively.