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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 141947, 5 pages
http://dx.doi.org/10.1155/2012/141947
Research Article

Inhibitory Effect of Helicteres gardneriana Ethanol Extract on Acute Inflammation

1Laboratory of Inflammation, Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR, Brazil
2Laboratory of Pharmaceutical Technology, Department of Pharmacy, State University of Maringá, Maringá, PR, Brazil

Received 16 June 2011; Revised 6 August 2011; Accepted 16 August 2011

Academic Editor: Ulysses Paulino De Albuquerque

Copyright © 2012 Juliana Oliveira de Melo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The anti-inflammatory effect of an ethanol extract of Helicteres gardneriana (Nees) Castiglioni was assayed in experimental models of pleurisy and microcirculation in situ. Treatment of animals with 500 mg/kg body weight reduced the exudate volume (35% reduction) induced by intrapleural injection of carrageenan and the migration of polymorphonuclear cells into the inflamed pleural cavity of rats (40%). Additionally, rolling and adhesion of leukocytes and the number of leukocytes that migrated toward the perivascular space in response to the carrageenan injection were decreased by the extract (500 mg/kg). These data demonstrate the anti-inflammatory effect of the ethanol extract of Helicteres gardneriana and imply that inhibition of leukocyte-endothelial interactions is important in the extract's mechanism of action.