Inhibitory Effect of Helicteres gardneriana Ethanol Extract on Acute Inflammation

Table 1

Exudate volume and total and differential leukocytes counts in inflammatory pleural Exudate of rats, 4 h after injection of carrageenan (Cg, 200 μg/cavity).

Groups of animals	Exudate volume (mL)	Leukocytes/mm^3
		Total	mononuclear	Polymorphonuclear
Basal	0.10±0.01	6700±450	1800±160	4900±390
Cg + Sal	0.91±0.07^c	59800±4810^c	11770±107^c	48030±4176^c
Cg + DMSO	0.90±0.07^c	60270±3910^c	9850±1333^c	50420±2999^c
Cg + Dex0.5	0.24±0.01^e	28000±1447^a,e	2309±324^b,e	25691±1355^b,e
Cg + EEHg250	0.85±0.10^c	58090±3986^c	9040±1361^c	49050±3059^c
Cg + EEHg500	0.63±0.04^c,d	41860±3434^c,d	13080±1409^c	28780±2573^b,d

Each value represents the mean ± S.E.M. of 6–8 animals. Dexamethasone (Dex) administered orally, 0.5 mg/Kg was used as a reference anti-inflammatory (positive control). Basal = animals that received injection of PBS in the cavity (PBS + Sal), Cg = carrageenan, Sal = 0.9% saline, DMSO = 16% dimethylsulfoxide, EEHg = ethanol extract of Helicteres gardneriana. ^a𝑃<0.05, ^b𝑃<0.01, and ^c𝑃<0.001, compared to basal group, ^d𝑃<0.05, ^e𝑃<0.001 compared to groups Cg + Sal and Cg + DMSO (one-way ANOVA, Tukey’s test).