Isolation of Antidiabetic Principle from Fruit Rinds of Punica granatum

Table 6

Effect of repeated-dose oral administration of MEPG and VAD on oral glucose tolerance test (OGTT) in alloxan-induced diabetic rats on the 21st day.

Group	Treatment	Blood glucose (mg/dL)
		0 min	30 min	60 min	120 min	180 min
G-I	Normal control	91.54±3.1	135.45±3.5	175.68±4.8	124.56±4.9	94.556±2.8
G-II	Vehicle control (3% Tween 80) 10 mL/kg, p.o.	274.84±5.7^#	384.11±4.75^#	471.25±6.7^#	352.12±7.4^#	330.23±8.5^#
G-III	Glibenclamide-10 mg/kg, p.o.	94.47±2.9	115.46±3.5^∗	124.56±3.4^∗	102.56±4.1^∗	96.56±4.2^∗
G-IV	MEPG-200 mg/kg, p.o.	132.44±7.2	164.56±7.2^∗	186.35±6.2^∗	148.90±5.2^∗	135.65±3.1^∗
G-V	MEPG-400 mg/kg, p.o.	115.27±4.9	139.25±6.3^∗	162.30±4.2^∗	129.34±5.2^∗	113.25±6.2^∗
G-VI	VAD-10 mg/kg, p.o.	124.66±4.1	147.65±3.2^∗	172.31±6.8^∗	138.56±3.9^∗	127.65±4.7^∗
G-VII	VAD-25 mg/kg, p.o.	98.26±2.15	138.69±6.4^∗	151.26±4.1^∗	119.87±6.3^∗	102.65±5.8^∗
G-VIII	VAD-50 mg/kg, p.o.	95.12. ±3.85	118.65±6.2^∗	121.45±2.3^∗	99.56±5.9^∗	92.65±3.7^∗

All the values are expressed as mean ± SEM, ^#𝑃<0.05 compared to normal control, and ^∗𝑃<0.05 compared to vehicle control (3% Tween 80).