Isolation of Antidiabetic Principle from Fruit Rinds of Punica granatum

Table 7

Effect of repeated-dose oral administration of MEPG and VAD on body weight in alloxan-induced diabetic rats.

Group	Treatment	Body weight (g)
		Day 1	Day 7	Day 14	Day 21
G-I	Normal control	238.45±6.5	246.85±7.1	251.63±4.9	254.85±7.3
G-II	Vehicle control (3% Tween 80) 10 mL/kg, p.o.	243.56±6.4	186.23±8.7^#	169.74±7.0^#	151.65±6.9^#
G-III	Glibenclamide-10 mg/kg, p.o.	241.58±8.2	236.56±4.5^∗	233.84±5.2^∗	229.56±8.2^∗
G-IV	MEPG-200 mg/kg, p.o.	240.65±6.9	199.23±4.9^∗	172.94±9.1^∗	162.75±7.9^∗
G-V	MEPG-400 mg/kg, p.o.	247.23±6.1	232.12±7.2^∗	224.23±7.3^∗	204.11±10.5^∗
G-VI	VAD-10 mg/kg, p.o.	236.52±8.4	210.41±5.9^∗	189.68 ±7.7^∗	174.55±9.5^∗
G-VII	VAD-25 mg/kg, p.o.	242.95±7.6	219.64±6.6^∗	212.47±5.9^∗	205.56±7.8^∗
G-VIII	VAD-50 mg/kg, p.o.	243.57±6.3	234.85±8.4^∗	226.18±6.3^∗	210.38±9.4^∗

All the values are expressed as mean ± SEM, ^#𝑃<0.05 compared to normal control, and ^∗𝑃<0.05 compared to vehicle control (3% Tween 80) on corresponding day.