Evidence for Inhibitory Effects of Flupirtine, a Centrally Acting Analgesic, on Delayed Rectifier K+ Currents in Motor Neuron-Like Cells
Figure 7
Inhibitory effect of Flu on in NG108-15 neuronal cells. Cells were bathed in Ca2+-free Tyrode’s solution and was elicited by the depolarizing pulse from −50 to +50 mV with a duration of 10 sec. a: control; b: 1 M Flu; c: 3 M Flu. The inset indicates the voltage protocol used. Notably, addition of Flu increases the inactivation rate along with the reduced current amplitude.
