A Standardized Chinese Herbal Decoction, Kai-Xin-San, Restores Decreased Levels of Neurotransmitters and Neurotrophic Factors in the Brain of Chronic Stress-Induced Depressive Rats
KXS increases the sucrose consumption in CMS-treated rats. (a) Five groups of rats were employed for the sucrose preference test, as stated in Figure 1. KXS treatment, intra-gastrically, was administrated daily at 30 min before the stress exposure for 4 weeks of experimental period. Two doses of KXS were applied including low dosage at 0.9 g/kg (KXS-L) and high dosage at 2.7 g/kg (KXS-H). Imipramine at daily dosage of 20 mg/kg was set as a positive control. (b) Treatment of KXS and imipramine as in (a) but these were all in normal rats. Values are expressed in the percentage of normal (unstressed, or no drug, control), as mean ± SEM (). *.