A Standardized Chinese Herbal Decoction, Kai-Xin-San, Restores Decreased Levels of Neurotransmitters and Neurotrophic Factors in the Brain of Chronic Stress-Induced Depressive Rats
KXS increases the mRNA expression of neurotrophic factors in depressive rats. The treatment of KXS in the rats was as that in Figure 2. The total RNA was isolated from the rat brains. The mRNA expression was analyzed by real-time quantitative PCR. Two doses of KXS were applied including low dosage at 0.9 g/kg (KXS-L) and high dosage at 2.7 g/kg (KXS-H). The imipramine at dose of 20 mg/kg was set as the positive control. Values are showed as the mean ± SEM (). *.